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    ELAVL2 ELAV like RNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 1993, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ELAVL2provided by HGNC
    Official Full Name
    ELAV like RNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:3313
    See related
    Ensembl:ENSG00000107105 MIM:601673; AllianceGenome:HGNC:3313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUB; HELN1; HEL-N1
    Summary
    In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]
    Expression
    Biased expression in testis (RPKM 13.9) and brain (RPKM 8.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See ELAVL2 in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (23690104..23850601, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (23696100..23856586, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (23690102..23850599, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929563 Neighboring gene SUMO2 pseudogene 2 Neighboring gene NOP56 ribonucleoprotein pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:23747173-23747672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:23820186-23821072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:23821073-23821958 Neighboring gene uncharacterized LOC105375992 Neighboring gene NANOG hESC enhancer GRCh37_chr9:23831326-23831828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19816 Neighboring gene uncharacterized LOC105375993 Neighboring gene zinc finger protein 791 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood. Yuan SG, et al. Altern Ther Health Med, 2024 Jan. PMID 37773661
    2. Hel-N2: a novel isoform of Hel-N1 which is conserved in rat neural tissue and produced in early embryogenesis. King PH. Gene, 1994 Dec 30. PMID 7828887
    3. Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. Gao FB, et al. Proc Natl Acad Sci U S A, 1994 Nov 8. PMID 7972035, Free PMC Article
    4. Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization. Han J, et al. Genomics, 1996 Aug 15. PMID 8812435
    5. Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation. Gao FB, et al. J Cell Sci, 1996 Mar. PMID 8907704

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood.
      Title: Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood.
    2. Identification of Hub Genes Associated with Resistance to Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene Co-expression Network Analysis.
      Title: Identification of Hub Genes Associated with Resistance to Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene Co-expression Network Analysis.
    3. Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population.
      Title: Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population.
    4. Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells.
      Title: Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells.
    5. HuB and HuD repress telomerase activity by dissociating HuR from TERC.
      Title: HuB and HuD repress telomerase activity by dissociating HuR from TERC.
    6. Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
      Title: Targeting hub genes and pathways of innate immune response in COVID-19: A network biology perspective.
    7. HuB plays a major role in the activation of proto-oncogenes.
      Title: The neural ELAVL protein HuB enhances endogenous proto-oncogene activation.
    8. ELAVL2-regulated co-expression networks are also enriched for neurodevelopmental and synaptic genes, and include genes with human-specific patterns of expression in the frontal pole. Together, these data suggest that ELAVL2 regulation of transcript expression is critical for neuronal function and clinically relevant to autism
      Title: ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism.
    9. Tests for gene-environment interaction between these 33 genes and maternal smoking found evidence for interaction with two additional genes: GRID2 and ELAVL2 among European mothers
      Title: Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.
    10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A Bayesian approach to genetic association studies with family-based designs.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-11-28)

    ClinGen Genome Curation Page
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2018-11-28)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 2
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
    ELAV like neuron-specific RNA binding protein 2
    hu-antigen B
    nervous system-specific RNA-binding protein Hel-N1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016425.3 RefSeqGene

      Range
      29361..165497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001171195.2 → NP_001164666.1  ELAV-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001164666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 345
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_001171197.2 → NP_001164668.1  ELAV-like protein 2 isoform b

      See identical proteins and their annotated locations for NP_001164668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/TrEMBL
      B7Z5E0
      Related
      ENSP00000223951.5, ENST00000223951.10
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 345
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. NM_001351455.2 → NP_001338384.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS87645.1
      UniProtKB/TrEMBL
      A0A0A0MRX1, B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 388
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    4. NM_001351456.2 → NP_001338385.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    5. NM_001351457.2 → NP_001338386.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    6. NM_001351458.2 → NP_001338387.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    7. NM_001351459.2 → NP_001338388.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    8. NM_001351460.2 → NP_001338389.1  ELAV-like protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:64 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    9. NM_001351461.2 → NP_001338390.1  ELAV-like protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:64 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    10. NM_001351462.2 → NP_001338391.1  ELAV-like protein 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:64 → 386
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    11. NM_001351463.2 → NP_001338392.1  ELAV-like protein 2 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:64 → 386
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    12. NM_001351464.2 → NP_001338393.1  ELAV-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 374
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    13. NM_001351465.2 → NP_001338394.1  ELAV-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 374
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    14. NM_001351466.2 → NP_001338395.1  ELAV-like protein 2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:50 → 372
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    15. NM_001351467.2 → NP_001338396.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    16. NM_001351468.2 → NP_001338397.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    17. NM_001351469.2 → NP_001338398.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    18. NM_001351470.2 → NP_001338399.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    19. NM_001351471.2 → NP_001338400.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    20. NM_001351472.2 → NP_001338401.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Related
      ENSP00000369460.1, ENST00000380117.5
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    21. NM_001351473.2 → NP_001338402.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    22. NM_001351474.2 → NP_001338403.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    23. NM_001351475.2 → NP_001338404.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Related
      ENSP00000440998.1, ENST00000544538.5
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    24. NM_001351476.2 → NP_001338405.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    25. NM_001351477.2 → NP_001338406.1  ELAV-like protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 345
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    26. NM_001351478.2 → NP_001338407.1  ELAV-like protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 345
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    27. NM_001385693.1 → NP_001372622.1  ELAV-like protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (27) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2, 3, 26, 27 and 28 encode the same isoform (b).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS55298.1
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 345
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    28. NM_001385694.1 → NP_001372623.1  ELAV-like protein 2 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:50 → 360
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    29. NM_001385695.1 → NP_001372624.1  ELAV-like protein 2 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 375
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    30. NM_001385696.1 → NP_001372625.1  ELAV-like protein 2 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL365204, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:50 → 373
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    31. NM_001385697.1 → NP_001372626.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS87645.1
      UniProtKB/TrEMBL
      A0A0A0MRX1, B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 388
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    32. NM_001385698.1 → NP_001372627.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS87645.1
      UniProtKB/TrEMBL
      A0A0A0MRX1, B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 388
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    33. NM_001385699.1 → NP_001372628.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    34. NM_001385700.1 → NP_001372629.1  ELAV-like protein 2 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:64 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    35. NM_001385701.1 → NP_001372630.1  ELAV-like protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 374
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    36. NM_001385702.1 → NP_001372631.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    37. NM_001385703.1 → NP_001372632.1  ELAV-like protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 1. Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    38. NM_001385704.1 → NP_001372633.1  ELAV-like protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS87645.1
      UniProtKB/TrEMBL
      A0A0A0MRX1, B7Z5E0
      Related
      ENSP00000369453.4, ENST00000380110.8
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 388
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    39. NM_001385705.1 → NP_001372634.1  ELAV-like protein 2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    40. NM_001385707.1 → NP_001372636.1  ELAV-like protein 2 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL161628, AL445623
      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    41. NM_004432.5 → NP_004423.2  ELAV-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_004423.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform (a). Variants 1, 21, 22, 23, 24, 25 and 38 encode the same protein (isoform a).
      Source sequence(s)
      AL161628, AL445623
      Consensus CDS
      CCDS6515.1
      UniProtKB/Swiss-Prot
      D3DRK3, Q12926, Q13235, Q59G15, Q8NEM4, Q9H1Q8
      UniProtKB/TrEMBL
      B7Z5E0
      Related
      ENSP00000380479.2, ENST00000397312.7
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 358
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      23690104..23850601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422916.1 → XP_047278872.1  ELAV-like protein 2 isoform X11

    2. XM_011517779.4 → XP_011516081.1  ELAV-like protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011516081.1

      UniProtKB/TrEMBL
      A0A0A0MRX1, B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 388
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. XM_047422917.1 → XP_047278873.1  ELAV-like protein 2 isoform X12

    4. XM_011517778.3 → XP_011516080.2  ELAV-like protein 2 isoform X6

      UniProtKB/TrEMBL
      B7Z5E0

    5. XM_047422910.1 → XP_047278866.1  ELAV-like protein 2 isoform X3

    6. XM_047422909.1 → XP_047278865.1  ELAV-like protein 2 isoform X2

    7. XM_047422908.1 → XP_047278864.1  ELAV-like protein 2 isoform X1

    8. XM_047422911.1 → XP_047278867.1  ELAV-like protein 2 isoform X4

    9. XM_047422915.1 → XP_047278871.1  ELAV-like protein 2 isoform X10

    10. XM_017014415.2 → XP_016869904.1  ELAV-like protein 2 isoform X9

      UniProtKB/TrEMBL
      B7Z5E0

    11. XM_047422914.1 → XP_047278870.1  ELAV-like protein 2 isoform X8

    12. XM_011517786.3 → XP_011516088.1  ELAV-like protein 2 isoform X12

      See identical proteins and their annotated locations for XP_011516088.1

      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    13. XM_005251393.4 → XP_005251450.1  ELAV-like protein 2 isoform X12

      See identical proteins and their annotated locations for XP_005251450.1

      UniProtKB/TrEMBL
      B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:36 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    14. XM_011517780.4 → XP_011516082.1  ELAV-like protein 2 isoform X7

      See identical proteins and their annotated locations for XP_011516082.1

      UniProtKB/TrEMBL
      A0A0A0MRX1, B7Z5E0
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 388
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    15. XM_047422912.1 → XP_047278868.1  ELAV-like protein 2 isoform X5

    16. XM_017014426.2 → XP_016869915.1  ELAV-like protein 2 isoform X15

      Conserved Domains (1) summary
      TIGR01661
      Location:1 → 224
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    17. XM_047422918.1 → XP_047278874.1  ELAV-like protein 2 isoform X13

    18. XM_047422920.1 → XP_047278876.1  ELAV-like protein 2 isoform X14

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      23696100..23856586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362248.1 → XP_054218223.1  ELAV-like protein 2 isoform X11

    2. XM_054362243.1 → XP_054218218.1  ELAV-like protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0A0MRX1

    3. XM_054362250.1 → XP_054218225.1  ELAV-like protein 2 isoform X12

    4. XM_054362242.1 → XP_054218217.1  ELAV-like protein 2 isoform X6

    5. XM_054362239.1 → XP_054218214.1  ELAV-like protein 2 isoform X3

    6. XM_054362238.1 → XP_054218213.1  ELAV-like protein 2 isoform X2

    7. XM_054362237.1 → XP_054218212.1  ELAV-like protein 2 isoform X1

    8. XM_054362240.1 → XP_054218215.1  ELAV-like protein 2 isoform X4

    9. XM_054362247.1 → XP_054218222.1  ELAV-like protein 2 isoform X10

    10. XM_054362246.1 → XP_054218221.1  ELAV-like protein 2 isoform X9

    11. XM_054362245.1 → XP_054218220.1  ELAV-like protein 2 isoform X8

    12. XM_054362244.1 → XP_054218219.1  ELAV-like protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A0A0MRX1

    13. XM_054362251.1 → XP_054218226.1  ELAV-like protein 2 isoform X12

    14. XM_054362249.1 → XP_054218224.1  ELAV-like protein 2 isoform X12

    15. XM_054362241.1 → XP_054218216.1  ELAV-like protein 2 isoform X5

    16. XM_054362254.1 → XP_054218229.1  ELAV-like protein 2 isoform X15

    17. XM_054362252.1 → XP_054218227.1  ELAV-like protein 2 isoform X13

    18. XM_054362253.1 → XP_054218228.1  ELAV-like protein 2 isoform X14

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12926.2 GenPept UniProtKB/Swiss-Prot:Q12926

    Gene LinkOut

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