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    SIRB sirohydrochlorin ferrochelatase B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841439, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SIRB
    Official Full Name
    sirohydrochlorin ferrochelatase B
    Primary source
    TAIR:AT1G50170
    Locus tag
    AT1G50170
    See related
    Araport:AT1G50170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSIRB; F14I3.20; F14I3_20; sirohydrochlorin ferrochelatase B
    Summary
    encodes sirohydrochlorin ferrochelatase catalyzing the last step of the siroheme biosynthesis
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    Genomic context

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    See SIRB in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (18581998..18583832)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ribonuclease H superfamily polynucleotidyl transferase Neighboring gene NB-ARC domain-containing disease resistance protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the evolutionarily conserved iron-sulfur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana. Saha K, et al. Biochem J, 2012 Jun 1. PMID 22414210
    2. Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center. Raux-Deery E, et al. J Biol Chem, 2005 Feb 11. PMID 15545265
    3. Enhanced tolerance to oxidative stress in transgenic Arabidopsis plants expressing proteins of unknown function. Luhua S, et al. Plant Physiol, 2008 Sep. PMID 18614705, Free PMC Article
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Arabidopsis thaliana the ferrochelation step is catalyzed by sirohydrochlorin ferrochelatase (SirB), which, unlike its counterparts in bacteria, contains a [4Fe-4S] type cluster which has an important physiological role in plants.
      Title: Characterization of the evolutionarily conserved iron-sulfur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana.
    2. the plastid-located sirohydrochlorin ferrochelatase contains a 2FE-2S center [At-SirB]
      Title: Identification and characterization of the terminal enzyme of siroheme biosynthesis from Arabidopsis thaliana: a plastid-located sirohydrochlorin ferrochelatase containing a 2FE-2S center.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001333424.1
    NM_001333425.1
    NM_103902.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sirohydrochlorin ferrochelatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within siroheme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in siroheme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    sirohydrochlorin ferrochelatase B
    NP_564562.1
    • sirohydrochlorin ferrochelatase B (SIRB); FUNCTIONS IN: sirohydrochlorin ferrochelatase activity; INVOLVED IN: response to oxidative stress, siroheme biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12) biosynthesis CbiX (InterPro:IPR002762); Has 1927 Blast hits to 1707 proteins in 620 species: Archae - 186; Bacteria - 1447; Metazoa - 1; Fungi - 0; Plants - 45; Viruses - 0; Other Eukaryotes - 248 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18581998..18583832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103902.4 → NP_564562.1  sirohydrochlorin ferrochelatase B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JH7, Q8L8S7, Q9SX37
      UniProtKB/TrEMBL
      A0A178WMV1, A0A5S9WNM8
      Conserved Domains (2) summary
      PLN02757
      Location:72 → 222
      PLN02757; sirohydrochlorine ferrochelatase
      COG2138
      Location:83 → 215
      SirB; Sirohydrochlorin ferrochelatase [Coenzyme transport and metabolism]

    2. NM_001333424.1 → NP_001323380.1  sirohydrochlorin ferrochelatase B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WMV1, A0A1P8AWW0, A0A5S9WNM8

    3. NM_001333425.1 → NP_001323379.1  sirohydrochlorin ferrochelatase B [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WMV1, A0A1P8AWY5, A0A5S9WNM8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JH7.1

    Gene LinkOut

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