PMM [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PMM
Primary source: Araport:AT2G45790
Locus tag: AT2G45790
See related: TAIR:AT2G45790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPMM; F4I18.23; phosphomannomutase; PHOSPHOMANNOMUTASE
Summary: encodes a phosphomannomutase, involved in ascorbate biosynthesis
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Genomic context

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See PMM in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 10

Sequence:: Chromosome: 2; NC_003071.7 (18855675..18858018)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PMM interacted specifically with CML10 in the presence of Ca(2+) through its multiple interaction motifs.PMM is an enzyme which modulates the biosynthesis of ascorbic acid.
Title: CML10, a variant of calmodulin, modulates ascorbic acid synthesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130142.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphomannomutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphomannomutase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-ascorbic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: phosphomannomutase

NP_182103.1

phosphomannomutase (PMM); FUNCTIONS IN: protein binding, phosphomannomutase activity; INVOLVED IN: L-ascorbic acid biosynthetic process, response to salt stress, mannose biosynthetic process; LOCATED IN: cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Eukaryotic phosphomannomutase (InterPro:IPR005002), HAD-superfamily hydrolase, subfamily IIB (InterPro:IPR006379); Has 1083 Blast hits to 1081 proteins in 282 species: Archae - 1; Bacteria - 92; Metazoa - 201; Fungi - 171; Plants - 223; Viruses - 0; Other Eukaryotes - 395 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18855675..18858018

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130142.4 → NP_182103.1 phosphomannomutase [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O80840, Q1W379

UniProtKB/TrEMBL

A0A178W2D7, A0A5S9X7B1, A0A7G2EHQ0

Conserved Domains (1) summary

PLN02423
Location:1 → 245

PLN02423; phosphomannomutase