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    SHM2 glycine hydroxymethyltransferase SHM2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850747, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SHM2
    Official Full Name
    glycine hydroxymethyltransferase SHM2
    Primary source
    SGD:S000004048
    Locus tag
    YLR058C
    See related
    AllianceGenome:SGD:S000004048; FungiDB:YLR058C; VEuPathDB:YLR058C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SHMT2
    Summary
    Enables glycine hydroxymethyltransferase activity. Involved in one-carbon metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in breast cancer and neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities. Orthologous to several human genes including SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SHM2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (257992..259401, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene C-5 sterol desaturase Neighboring gene putative mannosidase MNL2 Neighboring gene Rex2p Neighboring gene phenylalanine--tRNA ligase subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two forms of serine transhydroxymethylase, one absent in a thymidylate-less mutant in Saccharomyces cerevisiae. Zelikson R, et al. Eur J Biochem, 1976 Apr 15. PMID 6271
    2. Dissecting yeast Hog1 MAP kinase pathway using a chemical genetic approach. Kim S, et al. FEBS Lett, 2007 Mar 20. PMID 17346711
    3. Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase. McDonald RC, et al. BMC Mol Cell Biol, 2020 Nov 30. PMID 33256608, Free PMC Article
    4. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Kastanos EK, et al. Biochemistry, 1997 Dec 2. PMID 9398220
    5. Cloning and molecular characterization of three genes, including two genes encoding serine hydroxymethyltransferases, whose inactivation is required to render yeast auxotrophic for glycine. McNeil JB, et al. J Biol Chem, 1994 Mar 25. PMID 8132653

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SHM2 is a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.
      Title: Serine hydroxymethyltransferase: a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycine hydroxymethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine hydroxymethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycine hydroxymethyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    glycine hydroxymethyltransferase SHM2
    NP_013159.1
    • Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      257992..259401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181945.1 → NP_013159.1  TPA: glycine hydroxymethyltransferase SHM2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY60, P37291
      UniProtKB/TrEMBL
      A7A0W4, B3LT29, C7GQN5, C8ZD30, G2WIQ1, N1NY19
      Conserved Domains (1) summary
      pfam00464
      Location:17 → 416
      SHMT; Serine hydroxymethyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37291.2

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