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    GLN1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856147, updated on 22-Aug-2024

    Summary

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    Official Symbol
    GLN1
    Primary source
    FungiDB:YPR035W
    Locus tag
    YPR035W
    See related
    SGD:S000006239; AllianceGenome:SGD:S000006239; VEuPathDB:YPR035W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glutamate-ammonia ligase activity. Involved in glutamine biosynthetic process. Located in nuclear periphery. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia ligase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (642208..643320)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene histidine--tRNA ligase Neighboring gene Arp7p Neighboring gene H(+)-transporting V1 sector ATPase subunit H Neighboring gene Spo24p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection. Crispim M, et al. PLoS Negl Trop Dis, 2018 Jan. PMID 29320490, Free PMC Article
    2. Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly. He YX, et al. Proteins, 2009 Jul. PMID 19322816
    3. A glutamine synthetase mutant of Saccharomyces cerevisiae shows defect in cell wall. Shimizu J, et al. J Gen Appl Microbiol, 1997 Jun. PMID 12501331
    4. Glutamine synthesis is a regulatory signal controlling glucose catabolism in Saccharomyces cerevisiae. Flores-Samaniego B, et al. J Bacteriol, 1993 Dec. PMID 7902349, Free PMC Article
    5. Biochemical and physiological aspects of glutamine synthetase inactivation in Saccharomyces cerevisiae. Mitchell AP, et al. J Biol Chem, 1984 Oct 10. PMID 6148344

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results point to the stress-related proteins Ahp1, Yhb1 and Oye2, as well as Gln1 and Kes1 as putative candidates for being evaluated as biomarkers for diagnostic assays of S. cerevisiae infections.
      Title: Immunoproteomic profiling of Saccharomyces cerevisiae systemic infection in a murine model.
    2. Comparative structure analysis suggests that citrate binding could induce structural fluctuation of the segment Leu293-Ala300, which may serve the role of guarding the glutamate entrance to the active sites.
      Title: Crystal structure of Saccharomyces cerevisiae glutamine synthetase Gln1 suggests a nanotube-like supramolecular assembly.
    3. Data suggested that Gpx3 protects GS from non-enzymatic proteolysis, thereby contributing to cell homeostasis when cell is exposed to oxidative stress.
      Title: Glutathione peroxidase 3 of Saccharomyces cerevisiae suppresses non-enzymatic proteolysis of glutamine synthetase in an activity-independent manner.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamine synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamine synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamine synthetase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glutamate--ammonia ligase
    NP_015360.2
    • Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      642208..643320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184132.2 → NP_015360.2  TPA: glutamate--ammonia ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015360.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W445, P32288, Q03959
      UniProtKB/TrEMBL
      A6ZWS8, B3LL96, C7GQA3, C8ZJ59, G2WPL3, N1P229
      Conserved Domains (1) summary
      PLN02284
      Location:19 → 352
      PLN02284; glutamine synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32288.4

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