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    APM4 Apm4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854092, updated on 1-Aug-2024

    Summary

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    Gene symbol
    APM4
    Gene description
    Apm4p
    Primary source
    FungiDB:YOL062C
    Locus tag
    YOL062C
    See related
    SGD:S000005423; AllianceGenome:SGD:S000005423; VEuPathDB:YOL062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AMP1
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis. Located in cytosol. Part of AP-2 adaptor complex. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See APM4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (210520..211995, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene 3'(2'),5'-bisphosphate nucleotidase Neighboring gene Crt10p Neighboring gene ribose phosphate diphosphokinase subunit PRS5 Neighboring gene Mam3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance. Mesecke N, et al. Mol Biol Cell, 2008 Jun. PMID 18400945, Free PMC Article
    2. Yeast endocytic adaptor AP-2 binds the stress sensor Mid2 and functions in polarized cell responses. Chapa-y-Lazo B, et al. Traffic, 2014 May. PMID 24460703, Free PMC Article
    3. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339
    4. Apm4, the mu subunit of yeast AP-2 interacts with Pkc1, and mutation of the Pkc1 consensus phosphorylation site Thr176 inhibits AP-2 recruitment to endocytic sites. Chapa-Y-Lazo B, et al. Commun Integr Biol, 2014. PMID 25346786, Free PMC Article
    5. Adaptor complex-independent clathrin function in yeast. Yeung BG, et al. Mol Biol Cell, 1999 Nov. PMID 10564262, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-2 adaptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Apm4p
    NP_014579.1
    • Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      210520..211995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183317.1 → NP_014579.1  TPA: Apm4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W205, Q99186
      UniProtKB/TrEMBL
      A6ZNE8, B3LIZ7, B5VRJ1, C7GK29, N1NXP4
      Conserved Domains (2) summary
      cd09251
      Location:207 → 490
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
      cd14836
      Location:1 → 142
      AP2_Mu_N; AP-2 complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99186.1

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