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    SPE2 adenosylmethionine decarboxylase SPE2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854105, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SPE2
    Gene description
    adenosylmethionine decarboxylase SPE2
    Primary source
    FungiDB:YOL052C
    Locus tag
    YOL052C
    See related
    SGD:S000005412; AllianceGenome:SGD:S000005412; VEuPathDB:YOL052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenosylmethionine decarboxylase activity. Involved in pantothenate biosynthetic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPE2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (232446..233636, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Aim39p Neighboring gene Ddr2p Neighboring gene ncRNA Neighboring gene Gal11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Legionella pneumophila requires polyamines for optimal intracellular growth. Nasrallah GK, et al. J Bacteriol, 2011 Sep. PMID 21742865, Free PMC Article
    2. Polyamine accumulation in transgenic tomato enhances the tolerance to high temperature stress. Cheng L, et al. J Integr Plant Biol, 2009 May. PMID 19508360
    3. Sensitivity of spermidine-deficient Saccharomyces cerevisiae to paromomycin. Balasundaram D, et al. Antimicrob Agents Chemother, 1999 May. PMID 10223963, Free PMC Article
    4. Sensitivity of polyamine-deficient Saccharomyces cerevisiae to elevated temperatures. Balasundaram D, et al. J Bacteriol, 1996 May. PMID 8626346, Free PMC Article
    5. Spermidine biosynthesis in Saccharomyces cerevisiae. Biosynthesis and processing of a proenzyme form of S-adenosylmethionine decarboxylase. Kashiwagi K, et al. J Biol Chem, 1990 Dec 25. PMID 2266128

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables adenosylmethionine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylmethionine decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosylmethionine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    adenosylmethionine decarboxylase SPE2
    NP_014590.1
    • S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      232446..233636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183306.1 → NP_014590.1  TPA: adenosylmethionine decarboxylase SPE2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014590.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W216, P21182
      UniProtKB/TrEMBL
      A0A6A5Q5U0, A6ZNF9, B3LJ08, B5VRK0, C7GK18, C8ZHR2, G2WMI3, N1NY29
      Conserved Domains (1) summary
      cl03253
      Location:28 → 396
      SAM_decarbox; Adenosylmethionine decarboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21182.1

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