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    Rtkn rhotekin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297383, updated on 10-Jul-2024

    Summary

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    Symbol
    Rtknprovided by RGD
    Full Name
    rhotekinprovided by RGD
    Primary source
    RGD:727874
    See related
    EnsemblRapid:ENSRNOG00000009022 AllianceGenome:RGD:727874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be active in actomyosin contractile ring. Orthologous to human RTKN (rhotekin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 67.7), Kidney (RPKM 44.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rtkn in Genome Data Viewer
    Location:
    4q34
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117198496..117215660)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115640813..115657952)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (114833453..114850705)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 1 Neighboring gene INO80 complex subunit B Neighboring gene uncharacterized LOC108350719 Neighboring gene WD repeat domain 54 Neighboring gene similar to human chromosome 2 open reading frame 81 Neighboring gene dynactin subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rhotekin modulates differentiation of cultured neural stem cells to neurons. Iwai T, et al. J Neurosci Res, 2012 Jul. PMID 22411704
    2. The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the RhoA and Akt/GSK3β signaling pathways. Park JH, et al. PLoS One, 2014. PMID 25268128, Free PMC Article
    3. Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Liu CA, et al. Oncogene, 2004 Nov 18. PMID 15480428
    4. MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. Zhou J, et al. Oncol Rep, 2017 Feb. PMID 27922690
    5. The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. Reynaud C, et al. J Biol Chem, 2000 Oct 27. PMID 10940294

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rhotekin is required for maintenance and survival of neurons and positively regulates differentiation and neurite outgrowth.
      Title: Rhotekin modulates differentiation of cultured neural stem cells to neurons.
    2. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
      Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in septin ring organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rhotekin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415851.2 → NP_001402780.1  rhotekin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6V7V1, Q6V7V2
      UniProtKB/TrEMBL
      A0A8I6G5K4, A6IAK9
      Related
      ENSRNOP00000032233.3, ENSRNOT00000031964.6

    2. NM_001415852.2 → NP_001402781.1  rhotekin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AIK7, A0A8I6G5K4
      Related
      ENSRNOP00000092765.1, ENSRNOT00000101909.2

    3. NM_001415853.2 → NP_001402782.1  rhotekin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6G5K4
      Related
      ENSRNOP00000099265.1, ENSRNOT00000124729.1

    4. NM_001415854.2 → NP_001402783.1  rhotekin isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    5. NM_184046.3 → NP_908935.1  rhotekin isoform 1

      See identical proteins and their annotated locations for NP_908935.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6V7V1, Q6V7V2
      UniProtKB/TrEMBL
      A0A8I6G5K4, A6IAK9
      Conserved Domains (3) summary
      smart00742
      Location:23 → 78
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam08174
      Location:104 → 257
      Anillin; Cell division protein anillin
      cl17171
      Location:296 → 406
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117198496..117215660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285792.1 → XP_063141862.1  rhotekin isoform X5

      UniProtKB/TrEMBL
      A0A8I6G5K4

    2. XM_063285795.1 → XP_063141865.1  rhotekin isoform X7

      UniProtKB/TrEMBL
      A0A8I6G5K4

    3. XM_039107325.2 → XP_038963253.1  rhotekin isoform X4

      UniProtKB/TrEMBL
      A0A8I6G5K4
      Conserved Domains (3) summary
      pfam08174
      Location:67 → 220
      Anillin; Cell division protein anillin
      cl00087
      Location:1 → 41
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl17171
      Location:259 → 369
      PH-like; Pleckstrin homology-like domain

    4. XM_063285797.1 → XP_063141867.1  rhotekin isoform X9

    5. XM_063285794.1 → XP_063141864.1  rhotekin isoform X7

      UniProtKB/TrEMBL
      A0A8I6G5K4

    6. XM_063285793.1 → XP_063141863.1  rhotekin isoform X6

      UniProtKB/TrEMBL
      A0A8I6G5K4

    7. XM_063285796.1 → XP_063141866.1  rhotekin isoform X8

    8. XM_008763038.4 → XP_008761260.1  rhotekin isoform X3

      See identical proteins and their annotated locations for XP_008761260.1

      UniProtKB/TrEMBL
      A0A8L2UPK3
      Conserved Domains (4) summary
      smart00742
      Location:80 → 135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:377 → 455
      PH; PH domain
      pfam08174
      Location:161 → 314
      Anillin; Cell division protein anillin
      cl17171
      Location:353 → 463
      PH-like; Pleckstrin homology-like domain

    9. XM_008763037.4 → XP_008761259.1  rhotekin isoform X2

      See identical proteins and their annotated locations for XP_008761259.1

      UniProtKB/TrEMBL
      A0A8L2UPK3
      Conserved Domains (4) summary
      smart00742
      Location:80 → 135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:307 → 385
      PH; PH domain
      pfam08174
      Location:161 → 244
      Anillin; Cell division protein anillin
      cl17171
      Location:283 → 393
      PH-like; Pleckstrin homology-like domain

    10. XM_008763034.4 → XP_008761256.1  rhotekin isoform X1

      See identical proteins and their annotated locations for XP_008761256.1

      UniProtKB/TrEMBL
      A0A8L2UPK3
      Related
      ENSRNOP00000069449.3, ENSRNOT00000079547.3
      Conserved Domains (4) summary
      smart00742
      Location:80 → 135
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      pfam00169
      Location:377 → 455
      PH; PH domain
      pfam08174
      Location:161 → 314
      Anillin; Cell division protein anillin
      cl17171
      Location:353 → 463
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6V7V2.1 GenPept UniProtKB/Swiss-Prot:Q6V7V2

    Gene LinkOut

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