Myoz1 myozenin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myoz1provided by RGD
Official Full Name: myozenin 1provided by RGD
Primary source: RGD:1561064
See related: EnsemblRapid:ENSRNOG00000040122 AllianceGenome:RGD:1561064
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561064
Summary: Predicted to enable cytoskeletal protein binding activity; molecular condensate scaffold activity; and protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; negative regulation of skeletal muscle tissue regeneration; and sarcomere organization. Predicted to act upstream of or within with a positive effect on skeletal muscle fiber adaptation. Predicted to be active in Z disc and actin cytoskeleton. Orthologous to human MYOZ1 (myozenin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 11409.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (3693576..3700831)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (3644333..3651584)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (4077066..4084306)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that under weightlessness conditions, in some muscle fibers with a large proportion of fast MHC isoforms, the increased expression of calsarcin--2 can prevent the compensatory enhancement of the calcineurin pathway
Title: Expression of calsarcin isoforms and myosin phenotype stabilization in transitional unloaded muscle.

Submit: New GeneRIF Correction

General gene information

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Markers

Myoz1 (e-PCR), detects polymorphism
- UniSTS:508568

RH134270 (e-PCR)
- UniSTS:217552

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FATZ binding	IBA Inferred from Biological aspect of Ancestor more info
enables FATZ binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables telethonin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect skeletal muscle fiber adaptation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myozenin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.