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    Larp4b La ribonucleoprotein 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307070, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Larp4bprovided by RGD
    Official Full Name
    La ribonucleoprotein 4Bprovided by RGD
    Primary source
    RGD:1310713
    See related
    EnsemblRapid:ENSRNOG00000015888 AllianceGenome:RGD:1310713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Larp5; RGD1310713
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of 3'-UTR-mediated mRNA stabilization and positive regulation of translation. Predicted to be located in nucleolus. Predicted to be active in cytoplasmic stress granule and cytosol. Orthologous to human LARP4B (La ribonucleoprotein 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 242.7), Adrenal (RPKM 239.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Larp4b in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (65813125..65908920, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (61138663..61217423, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (63236007..63317298)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene disco-interacting protein 2 homolog C Neighboring gene acireductone dioxygenase 1, pseudogene 1 Neighboring gene 60S ribosomal protein L22-like Neighboring gene uncharacterized LOC120097870 Neighboring gene GTP binding protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A stimulatory role for the La-related protein 4B in translation. Schäffler K, et al. RNA, 2010 Aug. PMID 20573744, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 4B
    Names
    La ribonucleoprotein domain family, member 4B
    La ribonucleoprotein domain family, member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107361.2 → NP_001100831.1  la-related protein 4B

      See identical proteins and their annotated locations for NP_001100831.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KN12
      Conserved Domains (2) summary
      cd08036
      Location:157 → 231
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:236 → 312
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      65813125..65908920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276485.1 → XP_063132555.1  la-related protein 4B isoform X4

      UniProtKB/TrEMBL
      A6KN12

    2. XM_063276484.1 → XP_063132554.1  la-related protein 4B isoform X3

      UniProtKB/TrEMBL
      D3ZF45

    3. XM_063276489.1 → XP_063132559.1  la-related protein 4B isoform X11

    4. XM_039095756.2 → XP_038951684.1  la-related protein 4B isoform X1

      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:259 → 335
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    5. XM_063276490.1 → XP_063132560.1  la-related protein 4B isoform X13

    6. XM_039095764.2 → XP_038951692.1  la-related protein 4B isoform X11

      Conserved Domains (2) summary
      cd08036
      Location:157 → 231
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:236 → 312
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_063276488.1 → XP_063132558.1  la-related protein 4B isoform X8

    8. XM_063276487.1 → XP_063132557.1  la-related protein 4B isoform X7

      UniProtKB/TrEMBL
      A0A8I6A8U8
      Related
      ENSRNOP00000089771.1, ENSRNOT00000120050.2

    9. XM_039095758.2 → XP_038951686.1  la-related protein 4B isoform X3

      UniProtKB/TrEMBL
      D3ZF45
      Related
      ENSRNOP00000055347.4, ENSRNOT00000058548.6
      Conserved Domains (2) summary
      cd08036
      Location:157 → 231
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:236 → 312
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_039095763.2 → XP_038951691.1  la-related protein 4B isoform X12

      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:259 → 335
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_039095762.2 → XP_038951690.1  la-related protein 4B isoform X10

      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:259 → 335
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_039095761.2 → XP_038951689.1  la-related protein 4B isoform X9

      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cl17169
      Location:259 → 335
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. XM_063276486.1 → XP_063132556.1  la-related protein 4B isoform X6

    14. XM_039095760.2 → XP_038951688.1  la-related protein 4B isoform X5

      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:259 → 335
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    15. XM_039095757.2 → XP_038951685.1  la-related protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A0G2K4I2
      Related
      ENSRNOP00000073054.2, ENSRNOT00000077471.3
      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:259 → 335
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    16. XM_039095755.2 → XP_038951683.1  la-related protein 4B isoform X1

      Conserved Domains (2) summary
      cd08036
      Location:180 → 254
      LARP_5; La RNA-binding domain of La-related protein 5
      cd12706
      Location:259 → 335
      RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

    RNA

    1. XR_010058882.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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