Cyb5r1 cytochrome b5 reductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyb5r1provided by RGD
Official Full Name: cytochrome b5 reductase 1provided by RGD
Primary source: RGD:1306084
See related: EnsemblRapid:ENSRNOG00000003973 AllianceGenome:RGD:1306084
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nqo3a2
Summary: Predicted to enable FAD binding activity. Predicted to be involved in sterol biosynthetic process. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Orthologous to human CYB5R1 (cytochrome b5 reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 151.5), Testes (RPKM 51.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (48401061..48407466)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45849017..45855458)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (51229697..51236447)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stimulation and clustering of cytochrome b5 reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis.
Title: Stimulation and clustering of cytochrome b5 reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

AI236231 (e-PCR)
- UniSTS:250485

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytochrome-b5 reductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH-cytochrome b5 reductase 1

Names: NAD(P)H:quinone oxidoreductase type 3, polypeptide A2; b5R.1

NP_001013144.1

EC 1.6.2.2

XP_038946644.1

EC 1.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013126.1 → NP_001013144.1 NADH-cytochrome b5 reductase 1

See identical proteins and their annotated locations for NP_001013144.1

Status: PROVISIONAL

Source sequence(s)

BC089945

UniProtKB/Swiss-Prot

Q5EB81

UniProtKB/TrEMBL

A6ICB8

Related

ENSRNOP00000057400.4, ENSRNOT00000060669.5

Conserved Domains (2) summary

cd06183
Location:49 → 305

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

PTZ00319
Location:8 → 305

PTZ00319; NADH-cytochrome B5 reductase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

48401061..48407466

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090716.2 → XP_038946644.1 NADH-cytochrome b5 reductase 1 isoform X1

Conserved Domains (1) summary

cd06183
Location:1 → 175

cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...