Camk4 calcium/calmodulin-dependent protein kinase IV [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camk4provided by RGD
Official Full Name: calcium/calmodulin-dependent protein kinase IVprovided by RGD
Primary source: RGD:2264
See related: EnsemblRapid:ENSRNOG00000020478 AllianceGenome:RGD:2264
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdpk; RATCCDPK
Summary: Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Is active in glutamatergic synapse and postsynapse. Biomarker of alcohol use disorder and withdrawal disorder. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 286.0), Brain (RPKM 259.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (24857152..25076054)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (24582988..24811918)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (25746878..25975962)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMK4 is a downstream effector of the alpha1G T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells.
Title: CaMK4 is a downstream effector of the α(1G) T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells.
study demonstrates that CaMKIV can relieve STZ-induced diabetic neuropathic pain.pCaMKIV can regulate the expression of High-mobility group box 1 based on both cellular and animal models.
Title: Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1.
We find that synaptic excitation and intrinsic excitability are coregulated in individual neurons through CaMKIV signaling, which is tightly controlled by neuronal activity. In contrast, synaptic inhibition is unaffected by changes in firing or CaMKIV signaling in individual neurons.
Title: All for One But Not One for All: Excitatory Synaptic Scaling and Intrinsic Excitability Are Coregulated by CaMKIV, Whereas Inhibitory Synaptic Scaling Is Under Independent Control.
Camk4 expression in the cortical subplate was prolonged in developmentally hypothyroid pups, whereas heavy Camk4 expression in layer VIb remains at P60. Abnormal expression of Camk4 might cause altered cortical connectivity.
Title: Late maternal hypothyroidism alters the expression of Camk4 in neocortical subplate neurons: a comparison with Nurr1 labeling.
We have determined that high levels of CaMKIV protein are expressed by IB4-binding sensory neurons of the dorsal root ganglion
Title: IB4-binding sensory neurons in the adult rat express a novel 3' UTR-extended isoform of CaMK4 that is associated with its localization to axons.
CaMKIV contributes to the diversity of dendrite arbors via restricted expression and regulation of distinct modes of dendrite elaboration.
Title: Calcium/calmodulin-dependent protein kinase IV mediates distinct features of basal and activity-dependent dendrite complexity.
These results suggest that NR2B-containing NMDARs have a positive role in regulating neural progenitor cell proliferation, which may be mediated through CaMKIV phosphorylation and subsequent induction of CREB activation.
Title: NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKIV/CREB pathway.
Study provides correlative evidence for the neuroprotective cascade of CaMKIV/ peroxisome proliferator-activated receptor gamma coactivator-1alpha in delayed neuronal cell death and mitochondrial biogenesis in the hippocampus
Title: Activation of calcium/calmodulin-dependent protein kinase IV and peroxisome proliferator-activated receptor γ coactivator-1α signaling pathway protects against neuronal injury and promotes mitochondrial biogenesis in the hippocampal CA1 subfield after transient global ischemia.
abnormal regulation of CaMKIV is a component of beta-cell dysfunction caused by high glucose.
Title: Calcium/calmodulin-dependent protein kinase IV involvement in the pathophysiology of glucotoxicity in rat pancreatic β-cells.
Activation of the CaMKK/CaMKIV cascade by exendin-4 stimulated ABCA1 gene transcription, indicating that exendin-4 plays an important role in insulin secretion and cholesterol ester content in pancreatic beta cells.
Title: Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF400657 (e-PCR)
- UniSTS:245012

RH137597 (e-PCR)
- UniSTS:219684

BE107932 (e-PCR)
- UniSTS:247120

STS-Z40708 (e-PCR)
- UniSTS:80211

D18Rat132 (e-PCR), detects polymorphism
- UniSTS:226926

RH138191 (e-PCR)
- UniSTS:220278

Camk4 (e-PCR), detects polymorphism
- UniSTS:526967

D18Rat66 (e-PCR), detects polymorphism
- UniSTS:226948

D18Chm2 (e-PCR)
- UniSTS:518020

AU047213 (e-PCR)
- UniSTS:110729

BE119628 (e-PCR)
- UniSTS:249233

d18mgh9 (e-PCR)
- UniSTS:121275

D18Wox14 (e-PCR)
- UniSTS:517856

D18Got37 (e-PCR)
- UniSTS:113379

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium/calmodulin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid dendritic cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron-neuron synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in positive regulation of myeloid dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type IV

Names: CAM kinase-GR; Calmodulin-dependent protein kinase IV; caMK IV; calspermin

NP_036859.2

EC 2.7.11.17

XP_006254585.3

EC 2.7.11.17

XP_038952502.1

EC 2.7.11.17

XP_063133166.1

EC 2.7.11.17

XP_063133167.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012727.3 → NP_036859.2 calcium/calmodulin-dependent protein kinase type IV

See identical proteins and their annotated locations for NP_036859.2

Status: PROVISIONAL

Source sequence(s)

BC128706

UniProtKB/Swiss-Prot

A1A5L5, P13234, Q63892

UniProtKB/TrEMBL

A6J2R5

Related

ENSRNOP00000027771.4, ENSRNOT00000027771.6

Conserved Domains (1) summary

cd14085
Location:38 → 331

STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

24857152..25076054

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254523.5 → XP_006254585.3 calcium/calmodulin-dependent protein kinase type IV isoform X2

UniProtKB/TrEMBL

A0A8L2UQP4, A6J2R2
XM_063277096.1 → XP_063133166.1 calcium/calmodulin-dependent protein kinase type IV isoform X1

UniProtKB/TrEMBL

A6J2R3

Related

ENSRNOP00000072926.3, ENSRNOT00000078822.3
XM_063277097.1 → XP_063133167.1 calcium/calmodulin-dependent protein kinase type IV isoform X4
XM_039096574.2 → XP_038952502.1 calcium/calmodulin-dependent protein kinase type IV isoform X3

Conserved Domains (1) summary

cl21453
Location:43 → 226

PKc_like; Protein Kinases, catalytic domain