Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrb1provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit beta1provided by RGD
Primary source: RGD:2649
See related: Ensembl:ENSRNOG00000002327 AllianceGenome:RGD:2649
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GARB1
Summary: Enables GABA receptor binding activity; GABA-A receptor activity; and ion channel activity. Involved in several processes, including cellular response to histamine; central nervous system neuron development; and response to progesterone. Located in several cellular components, including cytoplasm; dendrite; and nuclear envelope. Is integral component of plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 45. Orthologous to human GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 172.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (36434339..36917920, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (36068725..36548946, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (38631192..39112598, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stimulation of brain alpha7-nicotinic acetylcholine receptors suppresses the rat micturition through brain GABAergic receptors.
Title: Stimulation of brain α7-nicotinic acetylcholine receptors suppresses the rat micturition through brain GABAergic receptors.
In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ...
Title: The GABA(A) Receptor β Subunit Is Required for Inhibitory Transmission.
we conclude that is a greater contribution of beta(1) -subunit-containing GABA(A) receptors following oxygen and glucose deprivation in cerebellar Purkinje cells
Title: Alterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of β1 -subunit-containing receptors.
Bone marrow stem cells and adult stem cells were found to express GABA-A alpha2 and beta3, but not beta1 mRNA transcripts.
Title: Expression of functional γ-aminobutyric acid type A receptors in Schwann-like adult stem cells.
The endogenous sleep pathway in the hypothalamus operates through the beta1- containing GABAAR whereas inhibition of neuronal firing (anaesthesia) by low propofol doses relies on beta3- containing GABAAR.
Title: GABAA receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies.
Following spinal nerve ligation, activated microglia in the spinal cord modulate peripheral nerve injury-induced downregulation of GABA(B)R1a receptor expression in the spinal dorsal horn.
Title: p38/MAPK inhibitor modulates the expression of dorsal horn GABA(B) receptors in the spinal nerve ligation model of neuropathic pain.
beta1-containing GABA(A)Rs are expressed in the hypothalamus
Title: Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors.
GABA(B) receptors expressed by neurones in solitary nucleus may be involved in cardiovascular regulation and that changes in GABA(B) mRNA expression levels may contribute to the hypertensive state in SHR
Title: Increased GABA B receptor subtype expression in the nucleus of the solitary tract of the spontaneously hypertensive rat.
falling progesterone levels may be associated with expression of new receptors of the alpha4beta1delta subtype in periaqueductal gray
Title: Withdrawal from progesterone increases expression of alpha4, beta1, and delta GABA(A) receptor subunits in neurons in the periaqueductal gray matter in female Wistar rats.
In rats with hepatic encephalopathy, mRNA expression levels of GABA(A) receptor subunits alpha(1), beta(1), gamma(2) increase significantly in basal nuclei, substantia nigra and hippocampi
Title: Expression of gamma-aminobutyric acid A receptor subunits alpha1, beta1, gamma2 mRNA in rats with hepatic encephalopathy.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

U14418 (e-PCR)
- UniSTS:185621

D14Hmgc7 (e-PCR)
- UniSTS:463391

Gabrb1 (e-PCR), detects polymorphism
- UniSTS:506915

RH94648 (e-PCR)
- UniSTS:119895

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables GABA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity	TAS Traceable Author Statement more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to histamine	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	TAS Traceable Author Statement more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamma-aminobutyric acid signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GABA-A receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of GABA-A receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit beta-1

Names: GABA(A) receptor subunit beta-1; GABAAR subunit beta-1; Gamma-aminobutyric acid receptor beta 1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 1; gamma-aminobutyric acid type A receptor beta 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012956.2 → NP_037088.1 gamma-aminobutyric acid receptor subunit beta-1 precursor

See identical proteins and their annotated locations for NP_037088.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P15431

UniProtKB/TrEMBL

A6JD82

Related

ENSRNOP00000003170.5, ENSRNOT00000003170.4

Conserved Domains (1) summary

TIGR00860
Location:9 → 472

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

36434339..36917920 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272872.1 → XP_063128942.1 gamma-aminobutyric acid receptor subunit beta-1 isoform X1
XM_063272873.1 → XP_063128943.1 gamma-aminobutyric acid receptor subunit beta-1 isoform X1
XM_063272871.1 → XP_063128941.1 gamma-aminobutyric acid receptor subunit beta-1 isoform X1
XM_063272874.1 → XP_063128944.1 gamma-aminobutyric acid receptor subunit beta-1 isoform X2