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    Nfkbiz NFKB inhibitor zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304005, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Nfkbizprovided by RGD
    Official Full Name
    NFKB inhibitor zetaprovided by RGD
    Primary source
    RGD:1310834
    See related
    EnsemblRapid:ENSRNOG00000031163 AllianceGenome:RGD:1310834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mail; RGD1310834
    Summary
    Predicted to be involved in positive regulation of immune response; positive regulation of inflammatory response; and regulation of gene expression. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Predicted to be active in nucleus. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 74.7), Thymus (RPKM 56.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nfkbiz in Genome Data Viewer
    Location:
    11q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58251720..58279767)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44782676..44810722)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47243342..47271487)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481067 Neighboring gene centrosomal protein 97 Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene adaptor related protein complex 3 subunit sigma 1, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108352329

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis. Chung KW, et al. Oncotarget, 2017 Jan 31. PMID 28099916, Free PMC Article
    2. MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. Kitamura H, et al. FEBS Lett, 2000 Nov 17. PMID 11086164
    3. IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Rossato M, et al. Proc Natl Acad Sci U S A, 2012 Nov 6. PMID 23071313, Free PMC Article
    4. Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Jeltsch KM, et al. Nat Immunol, 2014 Nov. PMID 25282160
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest role for NF-kappaBIZ in age-associated progressive renal fibrosis via cytokine signaling.
      Title: Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables POU domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T-helper 1 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T-helper 17 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interleukin-17 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chronic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T-helper 17 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cisplatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to folic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skin development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skin epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spleen development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NF-kappa-B inhibitor zeta
    Names
    IkappaB-zeta
    molecule possessing ankyrin-repeats induced by lipopolysaccharide
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401430.1 → NP_001388359.1  NF-kappa-B inhibitor zeta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0G2K6U7
      Related
      ENSRNOP00000073948.2, ENSRNOT00000078856.3

    2. NM_001415136.1 → NP_001402065.1  NF-kappa-B inhibitor zeta

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A0G2K6U7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      58251720..58279767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088370.2 → XP_038944298.1  NF-kappa-B inhibitor zeta isoform X1

      UniProtKB/TrEMBL
      M5AJR0
      Conserved Domains (3) summary
      PHA03095
      Location:421 → 617
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:477 → 535
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:374 → 462
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039088371.2 → XP_038944299.1  NF-kappa-B inhibitor zeta isoform X2

      Conserved Domains (2) summary
      COG0666
      Location:465 → 574
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:468 → 502
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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