Cep63 centrosomal protein 63 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cep63provided by RGD
Official Full Name: centrosomal protein 63provided by RGD
Primary source: RGD:1561183
See related: EnsemblRapid:ENSRNOG00000008410 AllianceGenome:RGD:1561183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in DNA damage checkpoint signaling and non-membrane-bounded organelle assembly. Predicted to act upstream of or within several processes, including centrosome duplication; meiosis I; and negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole. Human ortholog(s) of this gene implicated in Seckel syndrome 6. Orthologous to human CEP63 (centrosomal protein 63). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 178.4), Thymus (RPKM 61.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (112041586..112093061, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (103162639..103214177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (111063988..111116014, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF390936 (e-PCR)
- UniSTS:249611

D9Mgc48e (e-PCR), detects polymorphism
- UniSTS:142790

AI012039 (e-PCR)
- UniSTS:250059

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in centriole replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centriole replication	ISO Inferred from Sequence Orthology more info
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
involved_in centriole replication	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic telomere clustering	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to centrosome	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within reciprocal meiotic recombination	ISO Inferred from Sequence Orthology more info
involved_in signal transduction in response to DNA damage	ISS Inferred from Sequence or Structural Similarity more info
involved_in spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centrosomal protein of 63 kDa

Names: centrosomal protein 63kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037772.1 → NP_001032861.2 centrosomal protein of 63 kDa isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

BC098948

UniProtKB/TrEMBL

A0A096MIU4, A6I2H5

Conserved Domains (1) summary

pfam17045
Location:56 → 318

CEP63; Centrosomal protein of 63 kDa
NM_001244805.1 → NP_001231734.1 centrosomal protein of 63 kDa isoform 2

See identical proteins and their annotated locations for NP_001231734.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

BC161815

UniProtKB/Swiss-Prot

Q4KLY0

UniProtKB/TrEMBL

A6I2H5

Related

ENSRNOP00000092635.1, ENSRNOT00000114079.2

Conserved Domains (1) summary

pfam17045
Location:18 → 280

CEP63; Centrosomal protein of 63 kDa

RNA

NR_045200.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC083632

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

112041586..112093061 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081193.2 → XP_038937121.1 centrosomal protein of 63 kDa isoform X1

UniProtKB/TrEMBL

A0A0G2JXF3

Conserved Domains (2) summary

pfam15921
Location:29 → 612

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:47 → 309

CEP63; Centrosomal protein of 63 kDa
XM_017595591.3 → XP_017451080.2 centrosomal protein of 63 kDa isoform X3

Conserved Domains (2) summary

COG1196
Location:3 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam17045
Location:1 → 189

CEP63; Centrosomal protein of 63 kDa
XM_039081195.2 → XP_038937123.1 centrosomal protein of 63 kDa isoform X2

Conserved Domains (2) summary

pfam15921
Location:1 → 583

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:18 → 280

CEP63; Centrosomal protein of 63 kDa
XM_039081196.2 → XP_038937124.1 centrosomal protein of 63 kDa isoform X2

Conserved Domains (2) summary

pfam15921
Location:1 → 583

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:18 → 280

CEP63; Centrosomal protein of 63 kDa
XM_039081191.2 → XP_038937119.1 centrosomal protein of 63 kDa isoform X1

UniProtKB/TrEMBL

A0A0G2JXF3

Related

ENSRNOP00000070249.3, ENSRNOT00000084413.3

Conserved Domains (2) summary

pfam15921
Location:29 → 612

CCDC158; Coiled-coil domain-containing protein 158

pfam17045
Location:47 → 309

CEP63; Centrosomal protein of 63 kDa
XM_039081199.2 → XP_038937127.1 centrosomal protein of 63 kDa isoform X4

UniProtKB/TrEMBL

A6I2H5

Related

ENSRNOP00000029550.6, ENSRNOT00000031313.8

Conserved Domains (2) summary

TIGR02168
Location:165 → 492

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17045
Location:47 → 309

CEP63; Centrosomal protein of 63 kDa
XM_063265227.1 → XP_063121297.1 centrosomal protein of 63 kDa isoform X1

UniProtKB/TrEMBL

A0A0G2JXF3

Related

ENSRNOP00000083027.2, ENSRNOT00000099786.2
XM_063265229.1 → XP_063121299.1 centrosomal protein of 63 kDa isoform X5