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    Trim14 tripartite motif-containing 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313236, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Trim14provided by RGD
    Official Full Name
    tripartite motif-containing 14provided by RGD
    Primary source
    RGD:1311514
    See related
    EnsemblRapid:ENSRNOG00000008922 AllianceGenome:RGD:1311514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of viral transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRIM14 (tripartite motif containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 68.8), Testes (RPKM 56.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim14 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65596149..65620434, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60800568..60824858, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (62128941..62154424, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene N-acetylneuraminate synthase Neighboring gene coronin 2A Neighboring gene uncharacterized LOC108350963 Neighboring gene uncharacterized LOC108350962 Neighboring gene TBC1 domain family, member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis. Xie X, et al. J Recept Signal Transduct Res, 2022 Apr. PMID 33691569
    2. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. Uchil PD, et al. J Virol, 2013 Jan. PMID 23077300, Free PMC Article
    3. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article
    4. The tripartite motif family identifies cell compartments. Reymond A, et al. EMBO J, 2001 May 1. PMID 11331580, Free PMC Article
    5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
      Title: Trim14-IκBα Signaling Regulates Chronic Inflammatory Pain in Rats and Osteoarthritis Patients.
    2. RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/beta-catenin signaling pathway through degrading TRIM14.
      Title: RNF125, transcriptionally regulated by NFATC2, alleviates osteoarthritis via inhibiting the Wnt/β-catenin signaling pathway through degrading TRIM14.
    3. Tripartite motif-containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
      Title: Tripartite motif‑containing 14 may aggravate cardiac hypertrophy via the AKT signalling pathway in neonatal rat cardiomyocytes and transgenic mice.
    4. Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-kappaB/NLRP3 pathway-mediated inflammation and apoptosis.
      Title: Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury through regulating NF-κB/NLRP3 pathway-mediated inflammation and apoptosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 14
    Names
    tripartite motif protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107934.3 → NP_001101404.1  tripartite motif-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_001101404.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IJC4, D3ZBI1
      Related
      ENSRNOP00000111077.1, ENSRNOT00000159497.1
      Conserved Domains (2) summary
      pfam00643
      Location:20 → 56
      zf-B_box; B-box zinc finger
      cd13738
      Location:204 → 376
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    2. NM_001399174.2 → NP_001386103.1  tripartite motif-containing protein 14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      B2RYH2
      Related
      ENSRNOP00000088241.1, ENSRNOT00000107290.2
      Conserved Domains (2) summary
      cd13738
      Location:267 → 439
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
      cd19768
      Location:20 → 63
      Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      65596149..65620434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238062.5 → XP_006238124.1  tripartite motif-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006238124.1

      Conserved Domains (1) summary
      cd13738
      Location:198 → 370
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    2. XM_006238061.4 → XP_006238123.1  tripartite motif-containing protein 14 isoform X1

      See identical proteins and their annotated locations for XP_006238123.1

      Conserved Domains (1) summary
      cd13738
      Location:198 → 370
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    3. XM_039109868.2 → XP_038965796.1  tripartite motif-containing protein 14 isoform X2

      Conserved Domains (1) summary
      cd13738
      Location:112 → 284
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

    4. XM_039109869.2 → XP_038965797.1  tripartite motif-containing protein 14 isoform X2

      Conserved Domains (1) summary
      cd13738
      Location:112 → 284
      SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
    Nucleotide Protein Strain
    Heading Accession and Version

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