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    Nherf4 NHERF family PDZ scaffold protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500986, updated on 10-Jul-2024

    Summary

    Official Symbol
    Nherf4provided by RGD
    Official Full Name
    NHERF family PDZ scaffold protein 4provided by RGD
    Primary source
    RGD:1559807
    See related
    EnsemblRapid:ENSRNOG00000008526 AllianceGenome:RGD:1559807
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pdzd3; RGD1559807
    Summary
    Predicted to enable several functions, including guanylate cyclase inhibitor activity; protein C-terminus binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in negative regulation of cGMP-mediated signaling and protein localization to plasma membrane. Predicted to be located in several cellular components, including apical junction complex; apical part of cell; and brush border. Predicted to be active in apical plasma membrane. Orthologous to human PDZD3 (PDZ domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 120.7), Brain (RPKM 9.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Nherf4 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53481209..53485793, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44584390..44588838, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48577905..48582353, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Cbl proto-oncogene Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene NLR family member X1 Neighboring gene ATP binding cassette subfamily G member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanylate cyclase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Na(+)/H(+) exchange regulatory cofactor NHE-RF4
    Names
    PDZ domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191996.1NP_001178925.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF4

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6GHV2
      Related
      ENSRNOP00000089170.2, ENSRNOT00000119340.2
      Conserved Domains (2) summary
      smart00228
      Location:260345
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:47127
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53481209..53485793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081937.2XP_038937865.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1

      UniProtKB/TrEMBL
      D4A7C5
      Related
      ENSRNOP00000011582.7, ENSRNOT00000011582.9
      Conserved Domains (2) summary
      smart00228
      Location:258343
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:45125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. XM_039081939.2XP_038937867.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X2

      Conserved Domains (1) summary
      cd00992
      Location:45125
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...