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    Adgrg2 adhesion G protein-coupled receptor G2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266735, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Adgrg2provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor G2provided by RGD
    Primary source
    RGD:628618
    See related
    EnsemblRapid:ENSRNOG00000032472 AllianceGenome:RGD:628618
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    He6; Re6; Gpr64
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in X-linked congenital bilateral absence of vas deferens. Orthologous to human ADGRG2 (adhesion G protein-coupled receptor G2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 13.0), Heart (RPKM 11.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adgrg2 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (38106067..38231286, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (34297402..34422590, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (36930186..37054968, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase with EF-hand domain 1 Neighboring gene metallothionein 1F Neighboring gene phosphorylase kinase regulatory subunit alpha 2 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene ribosomal protein S27a, pseudogene 5 Neighboring gene chaperonin containing TCP1 subunit 6A, pseudogene 17 Neighboring gene small integral membrane protein 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Obermann H, et al. Mol Reprod Dev, 2003 Jan. PMID 12420295
    2. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
    3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G2
    Names
    G-protein coupled receptor 64
    epididymis-specific protein 6
    re6 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270871.1 → NP_001257800.1  adhesion G-protein coupled receptor G2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001257800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL2
      Conserved Domains (2) summary
      cd15444
      Location:605 → 874
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:549 → 592
      GPS; GPCR proteolysis site, GPS, motif

    2. NM_001270872.1 → NP_001257801.1  adhesion G-protein coupled receptor G2 isoform 3

      See identical proteins and their annotated locations for NP_001257801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL1, A6IPL2
      Related
      ENSRNOP00000082277.1, ENSRNOT00000102123.2
      Conserved Domains (2) summary
      pfam01825
      Location:538 → 580
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:593 → 843
      7tm_4; Olfactory receptor

    3. NM_181366.2 → NP_852031.1  adhesion G-protein coupled receptor G2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_852031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q8CJ06, Q8CJ07, Q8CJ11
      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL2, A6IPL3
      Related
      ENSRNOP00000039239.3, ENSRNOT00000040770.7
      Conserved Domains (2) summary
      pfam01825
      Location:566 → 608
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:621 → 871
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      38106067..38231286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279828.1 → XP_063135898.1  adhesion G-protein coupled receptor G2 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL1, A6IPL2

    2. XM_039099514.2 → XP_038955442.1  adhesion G-protein coupled receptor G2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL2
      Conserved Domains (2) summary
      cd15444
      Location:605 → 874
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:549 → 592
      GPS; GPCR proteolysis site, GPS, motif

    3. XM_039099517.2 → XP_038955445.1  adhesion G-protein coupled receptor G2 isoform X6

      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL2
      Related
      ENSRNOP00000105097.1, ENSRNOT00000157644.1
      Conserved Domains (2) summary
      cd15444
      Location:580 → 849
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:524 → 567
      GPS; GPCR proteolysis site, GPS, motif

    4. XM_039099515.2 → XP_038955443.1  adhesion G-protein coupled receptor G2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QR31, A0A8L2QR66, A6IPL2
      Related
      ENSRNOP00000055623.3, ENSRNOT00000058833.5
      Conserved Domains (2) summary
      cd15444
      Location:594 → 863
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:538 → 581
      GPS; GPCR proteolysis site, GPS, motif

    5. XM_039099516.2 → XP_038955444.1  adhesion G-protein coupled receptor G2 isoform X5

      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL2
      Conserved Domains (2) summary
      cd15444
      Location:592 → 861
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:536 → 579
      GPS; GPCR proteolysis site, GPS, motif

    6. XM_039099518.2 → XP_038955446.1  adhesion G-protein coupled receptor G2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNY1
      Related
      ENSRNOP00000098802.1, ENSRNOT00000151795.1
      Conserved Domains (2) summary
      cd15444
      Location:606 → 875
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:550 → 593
      GPS; GPCR proteolysis site, GPS, motif

    7. XM_039099513.2 → XP_038955441.1  adhesion G-protein coupled receptor G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP75, A0A8L2QR31, A6IPL2
      Related
      ENSRNOP00000096191.2, ENSRNOT00000104690.2
      Conserved Domains (2) summary
      cd15444
      Location:606 → 875
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:550 → 593
      GPS; GPCR proteolysis site, GPS, motif

    8. XM_063279827.1 → XP_063135897.1  adhesion G-protein coupled receptor G2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QR31, A6IPL2

    9. XM_063279826.1 → XP_063135896.1  adhesion G-protein coupled receptor G2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP75, A0A8L2QR31, A6IPL2
      Related
      ENSRNOP00000055624.4, ENSRNOT00000058834.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJ11.1 GenPept UniProtKB/Swiss-Prot:Q8CJ11

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