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    St8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364901, updated on 17-Aug-2024

    Summary

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    Official Symbol
    St8sia5provided by RGD
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by RGD
    Primary source
    RGD:1302934
    See related
    EnsemblRapid:ENSRNOG00000022691 AllianceGenome:RGD:1302934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SATV; SIAT8E; SIAT8-E; ST8SiaV
    Summary
    Enables sialyltransferase activity. Involved in glycosphingolipid biosynthetic process. Located in Golgi membrane. Orthologous to human ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 83.1), Muscle (RPKM 36.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See St8sia5 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (73010235..73072984)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (70736395..70802537)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (73564010..73630256)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483057 Neighboring gene haloacid dehalogenase-like hydrolase domain containing 2 Neighboring gene katanin catalytic subunit A1 like 2 Neighboring gene protein inhibitor of activated STAT, 2 Neighboring gene uncharacterized LOC102552068 Neighboring gene uncharacterized LOC102551787 Neighboring gene lipoxygenase homology PLAT domains 1 Neighboring gene uncharacterized protein DDB_G0292186-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of St8sia5 increases over 15 fold at night in the rat pineal gland.
      Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-2,8-sialyltransferase 8E
    Names
    ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 5
    sialyltransferase 8E
    sialyltransferase St8Sia V
    NP_001400037.1
    NP_998793.2
    XP_038952939.1
    XP_038952940.1
    XP_038952941.1
    XP_038952943.1
    XP_063133565.1
    XP_063133566.1
    XP_063133567.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413108.1 → NP_001400037.1  alpha-2,8-sialyltransferase 8E isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018

    2. NM_213628.2 → NP_998793.2  alpha-2,8-sialyltransferase 8E isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      A0A0G2JV41, E9PU47, Q6ZXC8
      Related
      ENSRNOP00000107226.1, ENSRNOT00000165782.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      73010235..73072984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097012.2 → XP_038952940.1  alpha-2,8-sialyltransferase 8E isoform X2

      Related
      ENSRNOP00000033363.2, ENSRNOT00000035317.3
      Conserved Domains (1) summary
      pfam00777
      Location:118 → 371
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_039097011.2 → XP_038952939.1  alpha-2,8-sialyltransferase 8E isoform X1

      Related
      ENSRNOP00000069340.2, ENSRNOT00000077679.3
      Conserved Domains (1) summary
      pfam00777
      Location:154 → 407
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_063277495.1 → XP_063133565.1  alpha-2,8-sialyltransferase 8E isoform X3

    4. XM_063277496.1 → XP_063133566.1  alpha-2,8-sialyltransferase 8E isoform X4

    5. XM_063277497.1 → XP_063133567.1  alpha-2,8-sialyltransferase 8E isoform X5

    6. XM_039097013.2 → XP_038952941.1  alpha-2,8-sialyltransferase 8E isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:63 → 316
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_039097015.2 → XP_038952943.1  alpha-2,8-sialyltransferase 8E isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:44 → 297
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZXC8.2 GenPept UniProtKB/Swiss-Prot:Q6ZXC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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