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    Atp10a ATPase phospholipid transporting 10A (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365266, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Atp10aprovided by RGD
    Official Full Name
    ATPase phospholipid transporting 10A (putative)provided by RGD
    Primary source
    RGD:1306150
    See related
    EnsemblRapid:ENSRNOG00000056228 AllianceGenome:RGD:1306150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of membrane tubulation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Orthologous to human ATP10A (ATPase phospholipid transporting 10A (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 163.6), Lung (RPKM 56.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp10a in Genome Data Viewer
    Location:
    1q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (118692456..118866117)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (109556760..109730440)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (115973343..116141892)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097768 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 1 Neighboring gene ornithine decarboxylase 1, pseudogene 8 Neighboring gene protein BEX1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosylceramide flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase VA
    Names
    ATPase, class V, type 10A
    probable phospholipid-transporting ATPase VA
    NP_001135407.1
    XP_038940920.1
    XP_038940921.1
    XP_038940923.1
    XP_038940929.1
    XP_063125284.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141935.3 → NP_001135407.1  phospholipid-transporting ATPase VA

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JWQ8
      Related
      ENSRNOP00000069976.2, ENSRNOT00000080907.3
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      118692456..118866117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084993.2 → XP_038940921.1  phospholipid-transporting ATPase VA isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWQ8
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_063269214.1 → XP_063125284.1  phospholipid-transporting ATPase VA isoform X2

      UniProtKB/TrEMBL
      A6KD43

    3. XM_039084995.2 → XP_038940923.1  phospholipid-transporting ATPase VA isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWQ8
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    4. XM_039084992.2 → XP_038940920.1  phospholipid-transporting ATPase VA isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWQ8
      Conserved Domains (1) summary
      cd02073
      Location:65 → 1203
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    5. XM_039085001.2 → XP_038940929.1  phospholipid-transporting ATPase VA isoform X3

      UniProtKB/TrEMBL
      Q32Q02
      Conserved Domains (1) summary
      cl21460
      Location:258 → 763
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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