Gpr143 G protein-coupled receptor 143 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr143provided by RGD
Official Full Name: G protein-coupled receptor 143provided by RGD
Primary source: RGD:1565799
See related: EnsemblRapid:ENSRNOG00000003543 AllianceGenome:RGD:1565799
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565799
Summary: Predicted to enable L-DOPA receptor activity; amino acid binding activity; and dopamine binding activity. Predicted to be involved in several processes, including intracellular signal transduction; melanosome organization; and melanosome transport. Predicted to be located in several cellular components, including apical plasma membrane; lysosomal membrane; and melanosome. Predicted to be active in melanosome membrane and plasma membrane. Human ortholog(s) of this gene implicated in congenital nystagmus 6. Orthologous to human GPR143 (G protein-coupled receptor 143). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 4.0), Brain (RPKM 3.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (25498601..25523408)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (22002914..22027720)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (23668363..23693162)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
Title: Right ventricular overloading is attenuated in monocrotaline-induced pulmonary hypertension model rats with a disrupted Gpr143 gene, the gene that encodes the 3,4-l-dihydroxyphenyalanine (l-DOPA) receptor.
the unique distribution pattern of gene OA1 product GPR143 in the rat central nervous system central nervous system
Title: Localization of ocular albinism-1 gene product GPR143 in the rat central nervous system.
gpr143 acted as a functional receptor for DOPA in the nucleus tractus solitarii
Title: The protein Ocular albinism 1 is the orphan GPCR GPR143 and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134759 (e-PCR)
- UniSTS:218037

Gpr143 (e-PCR), detects polymorphism
- UniSTS:519405

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables L-DOPA binding	IBA Inferred from Biological aspect of Ancestor more info
enables L-DOPA binding	ISO Inferred from Sequence Orthology more info
enables L-DOPA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-DOPA receptor activity	ISO Inferred from Sequence Orthology more info
enables L-tyrosine binding	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine binding	ISO Inferred from Sequence Orthology more info
enables dopamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables dopamine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in melanosome localization	ISO Inferred from Sequence Orthology more info
involved_in melanosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of melanosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of melanosome transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
is_active_in melanosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: G-protein coupled receptor 143

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106958.1 → NP_001100428.1 G-protein coupled receptor 143

See identical proteins and their annotated locations for NP_001100428.1

Status: PROVISIONAL

Source sequence(s)

CH474014

UniProtKB/TrEMBL

A6K2D0, D4A082

Related

ENSRNOP00000004758.4, ENSRNOT00000004758.7

Conserved Domains (1) summary

pfam02101
Location:1 → 397

Ocular_alb; Ocular albinism type 1 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

25498601..25523408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099643.2 → XP_038955571.1 G-protein coupled receptor 143 isoform X1

Conserved Domains (1) summary

pfam02101
Location:1 → 238

Ocular_alb; Ocular albinism type 1 protein