Kif11 kinesin family member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif11provided by RGD
Official Full Name: kinesin family member 11provided by RGD
Primary source: RGD:621258
See related: EnsemblRapid:ENSRNOG00000056069 AllianceGenome:RGD:621258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Knsl1
Summary: Predicted to enable plus-end-directed microtubule motor activity and protein kinase binding activity. Predicted to be involved in mitotic spindle assembly and regulation of mitotic centrosome separation. Predicted to act upstream of or within mitotic centrosome separation and spindle assembly. Predicted to be located in cytosol; microtubule; and mitotic spindle. Predicted to be part of protein-containing complex. Predicted to be active in nucleus and spindle microtubule. Predicted to colocalize with spindle pole. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 252.4), Spleen (RPKM 142.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (244494916..244589250)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (235124371..235176760)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256035866..256088299)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Corticotropin releasing hormone act on CRHR1 to induce MKLP1 expression via the PLC/PKC signaling pathway.
Title: Corticotropin-releasing hormone stimulates mitotic kinesin-like protein 1 expression via a PLC/PKC-dependent signaling pathway in hippocampal neurons.
kinesin-5 works in part by antagonizing cytoplasmic dynein, and these motor-driven forces function together with the dynamic properties of the microtubules to determine whether MTs can enter the P-domain.
Title: Kinesin-5 is essential for growth-cone turning.
the motor and tail regions of MKLP1 are important and significant for its localization to the dendrites
Title: MKLP1 requires specific domains for its dendritic targeting.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142960 (e-PCR)
- UniSTS:232207

BF398586 (e-PCR)
- UniSTS:246842

Kifl1-ps (e-PCR), detects polymorphism
- UniSTS:166621

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic centrosome separation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF11

Names: kinesin-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001169112.1 → NP_001162583.1 kinesin-like protein KIF11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZY18, F1MAB8

Related

ENSRNOP00000072698.1, ENSRNOT00000079726.3

Conserved Domains (4) summary

smart00129
Location:18 → 366

KISc; Kinesin motor, catalytic domain. ATPase

cd01364
Location:16 → 368

KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins

pfam13931
Location:916 → 1052

Microtub_bind; Kinesin-associated microtubule-binding

pfam16043
Location:416 → 486

DUF4795; Domain of unknown function (DUF4795)