Arid2 AT-rich interaction domain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arid2provided by RGD
Official Full Name: AT-rich interaction domain 2provided by RGD
Primary source: RGD:1311105
See related: EnsemblRapid:ENSRNOG00000004831 AllianceGenome:RGD:1311105
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; nucleosome disassembly; and positive regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 267.6), Lung (RPKM 131.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (129326371..129443813)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (127447192..127565987)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (137680564..137798329)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D7Got154 (e-PCR)
- UniSTS:112703

BF398770 (e-PCR)
- UniSTS:246906

ARID2_3730 (e-PCR)
- UniSTS:462036

RH143678 (e-PCR)
- UniSTS:232924

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within coronary artery morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostatic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SWI/SNF complex	ISO Inferred from Sequence Orthology more info
part_of SWI/SNF superfamily-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 2

Names: AT rich interactive domain 2 (Arid-rfx like)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

129326371..129443813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_345867.10 → XP_345868.4 AT-rich interactive domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A6KC19, D3ZJU0

Related

ENSRNOP00000006970.6, ENSRNOT00000006970.10

Conserved Domains (3) summary

pfam01388
Location:19 → 101

ARID; ARID/BRIGHT DNA binding domain

pfam02257
Location:521 → 601

RFX_DNA_binding; RFX DNA-binding domain

pfam07223
Location:677 → 893

DUF1421; Protein of unknown function (DUF1421)
XM_063264356.1 → XP_063120426.1 AT-rich interactive domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

A6KC19

Related

ENSRNOP00000112346.1, ENSRNOT00000139404.1