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    Dnah12 dynein, axonemal, heavy chain 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252959, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Dnah12provided by RGD
    Official Full Name
    dynein, axonemal, heavy chain 12provided by RGD
    Primary source
    RGD:619990
    See related
    EnsemblRapid:ENSRNOG00000059865 AllianceGenome:RGD:619990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bm259
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of inner dynein arm. Orthologous to human DNAH12 (dynein axonemal heavy chain 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 131.8), Lung (RPKM 86.0) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p16
    Exon count:
    78
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1932776..2099391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1936354..2092663)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (2377218..2534130)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 4 Neighboring gene phosphodiesterase 12 Neighboring gene protein phosphatase 1, regulatory subunit 26, pseudogene 1 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene host cell factor C1 regulator 1-like Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats. Kirsch T, et al. Brain Res, 2001 Aug 10. PMID 11489260
    2. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
    3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 12
    Names
    axonemal dynein heavy chain 12-like protein
    dynein heavy chain 12, axonemal
    dynein, axonemal, heavy polypeptide 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419553.1 → NP_001406482.1  dynein axonemal heavy chain 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2K7D4
      Related
      ENSRNOP00000074159.2, ENSRNOT00000079215.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      1932776..2099391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275064.1 → XP_063131134.1  dynein axonemal heavy chain 12 isoform X1

      UniProtKB/TrEMBL
      A6KMJ8

    2. XM_063275066.1 → XP_063131136.1  dynein axonemal heavy chain 12 isoform X3

      UniProtKB/TrEMBL
      A6KMJ8

    3. XM_063275065.1 → XP_063131135.1  dynein axonemal heavy chain 12 isoform X2

      UniProtKB/TrEMBL
      A6KMJ8

    4. XM_063275067.1 → XP_063131137.1  dynein axonemal heavy chain 12 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K7D4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923J6.2 GenPept UniProtKB/Swiss-Prot:Q923J6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials