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    Zbtb7c zinc finger and BTB domain containing 7C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679155, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Zbtb7cprovided by RGD
    Official Full Name
    zinc finger and BTB domain containing 7Cprovided by RGD
    Primary source
    RGD:1591841
    See related
    EnsemblRapid:ENSRNOG00000047924 AllianceGenome:RGD:1591841
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of cell population proliferation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of fat cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be located in nucleus. Orthologous to human ZBTB7C (zinc finger and BTB domain containing 7C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 44.1), Kidney (RPKM 17.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb7c in Genome Data Viewer
    Location:
    18q12.2-q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (71716586..72045831)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (69441616..69765744)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (72124955..72462293)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene cap binding complex dependent translation initiation factor Neighboring gene uncharacterized LOC102548225 Neighboring gene uncharacterized LOC120098205 Neighboring gene uncharacterized LOC134483052 Neighboring gene uncharacterized LOC102556385 Neighboring gene large ribosomal subunit protein eL15-like Neighboring gene SMAD family member 2 Neighboring gene uncharacterized LOC102549578

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity. Reuter S, et al. EMBO J, 1998 Jan 2. PMID 9427755, Free PMC Article
    2. Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. Jeon BN, et al. J Lipid Res, 2012 Apr. PMID 22331133, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187929

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 7C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127375.1 → NP_001120847.1  zinc finger and BTB domain-containing protein 7C

      See identical proteins and their annotated locations for NP_001120847.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166476
      UniProtKB/TrEMBL
      A0A8I5ZST7, B2GV04
      Related
      ENSRNOP00000065115.1, ENSRNOT00000072519.3
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      71716586..72045831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097091.2 → XP_038953019.1  zinc finger and BTB domain-containing protein 7C isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZST7, B2GV04
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    2. XM_039097092.2 → XP_038953020.1  zinc finger and BTB domain-containing protein 7C isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZST7, B2GV04
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)

    3. XM_063277570.1 → XP_063133640.1  zinc finger and BTB domain-containing protein 7C isoform X1

      UniProtKB/TrEMBL
      B2GV04

    4. XM_063277571.1 → XP_063133641.1  zinc finger and BTB domain-containing protein 7C isoform X1

      UniProtKB/TrEMBL
      B2GV04

    5. XM_063277572.1 → XP_063133642.1  zinc finger and BTB domain-containing protein 7C isoform X1

      UniProtKB/TrEMBL
      B2GV04

    6. XM_039097094.2 → XP_038953022.1  zinc finger and BTB domain-containing protein 7C isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZST7, B2GV04
      Conserved Domains (3) summary
      COG5189
      Location:380 → 468
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:394 → 414
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18328
      Location:9 → 128
      BTB_POZ_ZBTB7C_ZBTB36; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C)
    Nucleotide Protein Strain
    Heading Accession and Version

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