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    Mia3 MIA SH3 domain ER export factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683007, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Mia3provided by RGD
    Official Full Name
    MIA SH3 domain ER export factor 3provided by RGD
    Primary source
    RGD:1591600
    See related
    EnsemblRapid:ENSRNOG00000059202 AllianceGenome:RGD:1591600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cargo receptor activity. Predicted to be involved in several processes, including COPII-coated vesicle cargo loading; cell migration involved in sprouting angiogenesis; and regulation of leukocyte migration. Predicted to act upstream of or within chondrocyte development; collagen fibril organization; and positive regulation of bone mineralization. Predicted to be located in endoplasmic reticulum exit site and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human MIA3 (MIA SH3 domain ER export factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 243.2), Heart (RPKM 213.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mia3 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97502040..97547155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94970421..95012071, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101727434..101770127, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096334 Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC120096335 Neighboring gene uncharacterized LOC108352586 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 4 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit A Neighboring gene uncharacterized LOC120096336 Neighboring gene HHIP like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TANGO is a tumor suppressor of malignant melanoma. Arndt S, et al. Int J Cancer, 2006 Dec 15. PMID 17044017
    2. Interactions of TANGO and leukocyte integrin CD11c/CD18 regulate the migration of human monocytes. Arndt S, et al. J Leukoc Biol, 2007 Dec. PMID 17726152
    3. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. Santos AJ, et al. J Cell Biol, 2016 May 9. PMID 27138255, Free PMC Article
    4. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Saito K, et al. Mol Biol Cell, 2011 Jul 1. PMID 21525241, Free PMC Article
    5. TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites. Saito K, et al. Cell, 2009 Mar 6. PMID 19269366

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cargo receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chondrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipoprotein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lymphocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization protein 1 homolog
    Names
    MIA family member 3, ER export factor
    melanoma inhibitory activity family, member 3
    melanoma inhibitory activity protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398684.1 → NP_001385613.1  transport and Golgi organization protein 1 homolog isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2JVM2, A0A8I6AGK4
      Related
      ENSRNOP00000100877.1, ENSRNOT00000162162.1
      Conserved Domains (3) summary
      PHA03307
      Location:1665 → 1920
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR04523
      Location:1230 → 1615
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cl17036
      Location:38 → 109
      SH3; Src Homology 3 domain superfamily

    2. NM_001398698.2 → NP_001385627.1  transport and Golgi organization protein 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K0A8
      Related
      ENSRNOP00000071370.3, ENSRNOT00000080170.3
      Conserved Domains (2) summary
      PHA03307
      Location:525 → 780
      PHA03307; transcriptional regulator ICP4; Provisional
      TIGR02168
      Location:79 → 457
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      97502040..97547155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091493.2 → XP_038947421.1  transport and Golgi organization protein 1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGK4
      Related
      ENSRNOP00000069539.3, ENSRNOT00000085600.3
      Conserved Domains (2) summary
      TIGR04523
      Location:1230 → 1615
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      cl17036
      Location:38 → 109
      SH3; Src Homology 3 domain superfamily

    2. XM_063272603.1 → XP_063128673.1  transport and Golgi organization protein 1 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0A8

    3. XM_063272604.1 → XP_063128674.1  transport and Golgi organization protein 1 homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0A8
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.