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    ERG27 3-keto-steroid reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850790, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ERG27
    Gene description
    3-keto-steroid reductase
    Primary source
    FungiDB:YLR100W
    Locus tag
    YLR100W
    See related
    SGD:S000004090; AllianceGenome:SGD:S000004090; VEuPathDB:YLR100W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-keto sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and lipid droplet. Used to study steroid inherited metabolic disorder. Orthologous to human HSD17B7 (hydroxysteroid 17-beta dehydrogenase 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ERG27 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (341810..342853)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid acyltransferase ICT1 Neighboring gene Mim2p Neighboring gene anaphase promoting complex subunit 9 Neighboring gene DNA replication initiation factor CDC45

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast. Yang C, et al. Phytochemistry, 2018 Nov. PMID 30077898
    2. 4-Methylzymosterone and Other Intermediates of Sterol Biosynthesis from Yeast Mutants Engineered in the ERG27 Gene Encoding 3-Ketosteroid Reductase. Ferrante T, et al. Lipids, 2016 Sep. PMID 27421732
    3. Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation. Gachotte D, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535978, Free PMC Article
    4. Difference in the late ergosterol biosynthesis between yeast spheroplasts and intact cells. Ferrante T, et al. Acta Biochim Pol, 2016. PMID 27031513
    5. Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts. Taramino S, et al. Biochim Biophys Acta, 2010 Nov. PMID 20659585, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast; results will help elucidate the biosynthetic pathways of ganoderic acids
      Title: Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast.
    2. This study provides new insights into the role of Erg27p in sterol biosynthesis.
      Title: Genetic analyses involving interactions between the ergosterol biosynthetic enzymes, lanosterol synthase (Erg7p) and 3-ketoreductase (Erg27p), in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-keto sterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-keto sterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-keto sterol reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 

    General protein information

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    Preferred Names
    3-keto-steroid reductase
    NP_013201.1
    • 3-keto sterol reductase; catalyzes last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; Erg27 protein is mainly ER-localized in strains devoid of mtDNA (rho cells); mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      341810..342853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181987.1 → NP_013201.1  TPA: 3-keto-steroid reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013201.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYA1, Q12452
      UniProtKB/TrEMBL
      A0A8H4F8D8, B3LT69, C7GQS4, C8ZD71, G2WIU4, N1NY57
      Conserved Domains (1) summary
      cd08941
      Location:3 → 293
      3KS_SDR_c; 3-keto steroid reductase, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12452.1

    Gene LinkOut

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