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    YAE1 Yae1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853530, updated on 19-Jun-2024

    Summary

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    Gene symbol
    YAE1
    Gene description
    Yae1p
    Primary source
    FungiDB:YJR067C
    Locus tag
    YJR067C
    See related
    SGD:S000003828; AllianceGenome:SGD:S000003828; VEuPathDB:YJR067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to protein-macromolecule adaptor activity. Involved in protein maturation by [4Fe-4S] cluster transfer. Located in cytoplasm and nucleus. Part of Yae1-Lto1 complex. Orthologous to human YAE1 (YAE1 maturation factor of ABCE1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YAE1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (567019..567444, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene actin-related protein 3 Neighboring gene phosphatidylinositol kinase-related protein kinase TOR1 Neighboring gene replication factor C subunit 2 Neighboring gene nucleoside triphosphate pyrophosphohydrolase HAM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation. Heuer A, et al. Nat Struct Mol Biol, 2017 May. PMID 28368393
    2. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279
    3. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Zhai C, et al. Oncogene, 2014 Jan 23. PMID 23318452
    4. A chemogenomic approach to understand the antifungal action of Lichen-derived vulpinic acid. Kwon Y, et al. J Appl Microbiol, 2016 Dec. PMID 27660105
    5. The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion. Paul VD, et al. Elife, 2015 Jul 16. PMID 26182403, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Collectively, the Yae1-Lto1 complex functions as a target-specific adaptor that recruits apo-Rli1 to the generic cytosolic iron-sulfur assembly machinery.
      Title: The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation by [4Fe-4S] cluster transfer IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Yae1-Lto1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yae1p
    NP_012601.1
    • Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human YAE1D1, which is overexpressed in oral cancers; co-expression of YAE1D1 and LTO1 homolog ORAOV1 restores growth and Rli1p maturation after YAE1 depletion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      567019..567444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181725.1 → NP_012601.1  TPA: Yae1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012601.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWN8, P47118
      UniProtKB/TrEMBL
      B3LQF4, C7GMD6, C8ZBL5
      Conserved Domains (1) summary
      pfam09811
      Location:34 → 72
      Yae1_N; Essential protein Yae1, N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47118.1

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