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    ERP2 Erp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851226, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ERP2
    Gene description
    Erp2p
    Primary source
    FungiDB:YAL007C
    Locus tag
    YAL007C
    See related
    SGD:S000000005; AllianceGenome:SGD:S000000005; VEuPathDB:YAL007C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein retention in ER lumen. Located in COPII-coated ER to Golgi transport vesicle. Orthologous to human TMED1 (transmembrane p24 trafficking protein 1) and TMED5 (transmembrane p24 trafficking protein 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ERP2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (137698..138345, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Nem1-Spo7 phosphatase regulatory subunit SPO7 Neighboring gene Fun14p Neighboring gene tRNA-Pro Neighboring gene Hsp70 family ATPase SSA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae. Springer S, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10737764, Free PMC Article
    2. Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex. Marzioch M, et al. Mol Biol Cell, 1999 Jun. PMID 10359606, Free PMC Article
    3. The GOLD domain, a novel protein module involved in Golgi function and secretion. Anantharaman V, et al. Genome Biol, 2002. PMID 12049664, Free PMC Article
    4. A class of membrane proteins shaping the tubular endoplasmic reticulum. Voeltz GK, et al. Cell, 2006 Feb 10. PMID 16469703
    5. Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum. Li S, et al. Mol Biol Cell, 2010 Aug 1. PMID 20519439, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genetic and physical interactions of p24alpha (Erp1, -5, and -6) and gamma (Erp2, -3, and -4). Deletion of the major p24alpha (Erp1) partially inhibited p24 activity as reported previously.
      Title: Isoform-selective oligomer formation of Saccharomyces cerevisiae p24 family proteins.
    2. Erp2p is required for the ER-Golgi cycling of ricin A chain prior to retrotranslocation from the yeast ER
      Title: Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
    3. Erp2p is required for the ER-Golgi cycling of ricin A chain expressed in the yeast ER lumen, prior to its dislocation and cytosolic entry
      Title: Folding-competent and folding-defective forms of ricin A chain have different fates after retrotranslocation from the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cargo receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erp2p
    NP_009395.1
    • Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      137698..138345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178152.1 → NP_009395.1  TPA: Erp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009395.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPL1, P39704
      UniProtKB/TrEMBL
      A0A6A5PZ78, A7A0G2, B3LUU4, B5VDL6, C7GPM7, C8Z3M3, G2W8M5, N1P8X3
      Conserved Domains (1) summary
      pfam01105
      Location:34 → 183
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39704.1

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