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    RPS0A ribosomal 40S subunit protein S0A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853128, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPS0A
    Official Full Name
    ribosomal 40S subunit protein S0A
    Primary source
    SGD:S000003446
    Locus tag
    YGR214W
    See related
    AllianceGenome:SGD:S000003446; FungiDB:YGR214W; VEuPathDB:YGR214W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAB1; NAB1A; YST1
    Summary
    A structural constituent of ribosome. Involved in cytoplasmic translation and ribosome biogenesis. Located in cytoplasmic stress granule. Part of cytosolic small ribosomal subunit. Orthologous to human RPSA (ribosomal protein SA). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPS0A in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (920575..921788)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase Neighboring gene Rta1p Neighboring gene mitochondrial 37S ribosomal protein RSM27 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of pathogenic yeast species by polymerase chain reaction amplification of the RPS0 gene intron fragment. Martínez JM, et al. J Appl Microbiol, 2010 Jun. PMID 19968730
    2. Yeast proteins related to the p40/laminin receptor precursor are required for 20S ribosomal RNA processing and the maturation of 40S ribosomal subunits. Ford CL, et al. Cancer Res, 1999 Feb 1. PMID 9973221
    3. Yeast proteins related to the p40/laminin receptor precursor are essential components of the 40 S ribosomal subunit. Demianova M, et al. J Biol Chem, 1996 May 10. PMID 8626693
    4. Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. Tabb AL, et al. Genetics, 2001 Mar. PMID 11238398, Free PMC Article
    5. Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA. Tabb-Massey A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627813, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction between the flexible RPS0A-C-terminal tail and residues 200-400 of the TIF32-N-terminal domain significantly stimulates attachment of eIF3 and its associated eIFs to small ribosomal subunits in vivo.
      Title: Small ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunit.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S0A
    NP_011730.1
    • Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      920575..921788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181343.1 → NP_011730.1  TPA: ribosomal 40S subunit protein S0A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011730.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZUM5, B3LI22, D6VUZ7, P32905
      UniProtKB/TrEMBL
      C8Z9A6, G2WEU3, N1P3Z7
      Conserved Domains (1) summary
      PTZ00254
      Location:1 → 252
      PTZ00254; 40S ribosomal protein SA; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32905.3

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