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    UTR4 putative acireductone synthase UTR4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856673, updated on 17-May-2024

    Summary

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    Gene symbol
    UTR4
    Gene description
    putative acireductone synthase UTR4
    Primary source
    FungiDB:YEL038W
    Locus tag
    YEL038W
    See related
    SGD:S000000764; AllianceGenome:SGD:S000000764; VEuPathDB:YEL038W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable acireductone synthase activity. Involved in L-methionine salvage from methylthioadenosine. Located in cytoplasm and nucleus. Orthologous to human ENOPH1 (enolase-phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UTR4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (80462..81145)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene chitin transglycosylase UTR2 Neighboring gene cytochrome c isoform 2 Neighboring gene Rad23p Neighboring gene Anp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry. Melnick L, et al. J Mol Biol, 1993 Oct 5. PMID 8411151
    2. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. Pirkov I, et al. FEBS J, 2008 Aug. PMID 18625006
    3. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. Kuznetsova E, et al. J Biol Chem, 2015 Jul 24. PMID 26071590, Free PMC Article
    4. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Blazeck J, et al. Appl Microbiol Biotechnol, 2014 Oct. PMID 24997118
    5. Bacterial variations on the methionine salvage pathway. Sekowska A, et al. BMC Microbiol, 2004 Mar 4. PMID 15102328, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acireductone synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acireductone synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acireductone synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from S-adenosylmethionine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative acireductone synthase UTR4
    NP_010876.2
    • Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      80462..81145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178853.1 → NP_010876.2  TPA: putative acireductone synthase UTR4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010876.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQR2, D3DLL1, P32626
      UniProtKB/TrEMBL
      A0A8H8ULH6, G2WCJ5
      Conserved Domains (1) summary
      cl21460
      Location:6 → 227
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32626.2

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