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    HAL9 Hal9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854064, updated on 29-Jun-2024

    Summary

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    Gene symbol
    HAL9
    Gene description
    Hal9p
    Primary source
    FungiDB:YOL089C
    Locus tag
    YOL089C
    See related
    SGD:S000005449; AllianceGenome:SGD:S000005449; VEuPathDB:YOL089C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and response to salt stress. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HAL9 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (150398..153490, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Spo21p Neighboring gene mismatch repair ATPase MSH2 Neighboring gene protein disulfide isomerase MPD2 Neighboring gene Duf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast putative transcription factors involved in salt tolerance. Mendizabal I, et al. FEBS Lett, 1998 Mar 27. PMID 9559673
    2. Basic functional analysis of six unknown open reading frames from Saccharomyces cerevisiae: four from chromosome VII and two from chromosome XV. Pearson BM, et al. Yeast, 2002 Jan 30. PMID 11788967
    3. Polygenic analysis of very high acetic acid tolerance in the yeast Saccharomyces cerevisiae reveals a complex genetic background and several new causative alleles. Stojiljkovic M, et al. Biotechnol Biofuels, 2020. PMID 32695222, Free PMC Article
    4. New regulators of drug sensitivity in the family of yeast zinc cluster proteins. Akache B, et al. J Biol Chem, 2002 Jun 14. PMID 11943786
    5. Sex alters molecular evolution in diploid experimental populations of S. cerevisiae. Leu JY, et al. Nat Ecol Evol, 2020 Mar. PMID 32042122

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hal9p
    NP_014552.1
    • Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      150398..153490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183343.1 → NP_014552.1  TPA: Hal9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014552.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1X9, Q12180
      UniProtKB/TrEMBL
      A0A8H4F8K5, N1NZ41
      Conserved Domains (2) summary
      smart00066
      Location:130 → 171
      GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
      pfam04082
      Location:390 → 653
      Fungal_trans; Fungal specific transcription factor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12180.1

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