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    ALF1 Alf1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855574, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALF1
    Official Full Name
    Alf1p
    Primary source
    SGD:S000005092
    Locus tag
    YNL148C
    See related
    AllianceGenome:SGD:S000005092; FungiDB:YNL148C; VEuPathDB:YNL148C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-tubulin binding activity and microtubule binding activity. Involved in post-chaperonin tubulin folding pathway. Located in cytoplasm and nucleus. Orthologous to human TBCB (tubulin folding cofactor B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ALF1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (349907..350671, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III subunit C31 Neighboring gene Pga2p Neighboring gene Sm-like protein LSM7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of 36.8 kb from the left arm of chromosome XIV reveals 24 complete open reading frames: 18 correspond to new genes, one of which encodes a protein similar to the human myotonic dystrophy kinase. Nasr F, et al. Yeast, 1996 Feb. PMID 8686380
    2. Microtubule dynamics at low temperature: evidence that tubulin recycling limits assembly. Li G, et al. Mol Biol Cell, 2020 May 15. PMID 32213119, Free PMC Article
    3. High copies of SUM1 enhance the stability of wild-type microtubules against adverse conditions in Saccharomyces cerevisiae. Haldar S, et al. Biochem Biophys Res Commun, 2012 Feb 17. PMID 22285862
    4. Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. Feierbach B, et al. J Cell Biol, 1999 Jan 11. PMID 9885248, Free PMC Article
    5. Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. Tian G, et al. J Cell Biol, 1997 Aug 25. PMID 9265649, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-chaperonin tubulin folding pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Alf1p
    NP_014251.1
    • Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      349907..350671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182986.1 → NP_014251.1  TPA: Alf1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W134, P53904
      UniProtKB/TrEMBL
      B3LP04, C7GXU9, C8ZG80, N1P498
      Conserved Domains (2) summary
      pfam01302
      Location:163 → 229
      CAP_GLY; CAP-Gly domain
      cl28922
      Location:2 → 67
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53904.1

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