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    APS3 Aps3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APS3
    Official Full Name
    Aps3p
    Primary source
    SGD:S000003561
    Locus tag
    YJL024C
    See related
    AllianceGenome:SGD:S000003561; FungiDB:YJL024C; VEuPathDB:YJL024C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YKS7
    Summary
    Involved in Golgi to vacuole transport and protein targeting to vacuole. Part of AP-3 adaptor complex. Orthologous to human AP3S1 (adaptor related protein complex 3 subunit sigma 1) and AP3S2 (adaptor related protein complex 3 subunit sigma 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APS3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    2
    Sequence:
    Chromosome: X; NC_001142.9 (395931..396592, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribonucleotide-diphosphate reductase subunit RNR2 Neighboring gene Rrn7p Neighboring gene tRNA-Gly Neighboring gene Pet130p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole. Vowels JJ, et al. EMBO J, 1998 May 1. PMID 9564031, Free PMC Article
    2. A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity. Garza NM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33662401, Free PMC Article
    3. The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. Stepp JD, et al. J Cell Biol, 1997 Dec 29. PMID 9412470, Free PMC Article
    4. The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane. Llinares E, et al. Sci Rep, 2015 Nov 18. PMID 26577948, Free PMC Article
    5. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aps3p
    NP_012510.3
    • Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      395931..396592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181458.3 → NP_012510.3  TPA: Aps3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012510.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWF8, P47064
      UniProtKB/TrEMBL
      A6ZPV0, B3LQ85, C7GSP9, C8ZBD5, G2WGZ2, N1P1E1
      Conserved Domains (1) summary
      COG5030
      Location:1 → 172
      APS2; Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47064.1

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