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    ARF2 Arf family GTPase ARF2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851418, updated on 17-May-2024

    Summary

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    Gene symbol
    ARF2
    Gene description
    Arf family GTPase ARF2
    Primary source
    FungiDB:YDL137W
    Locus tag
    YDL137W
    See related
    SGD:S000002296; AllianceGenome:SGD:S000002296; VEuPathDB:YDL137W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Involved in macroautophagy. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARF2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (216529..217074)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Scm3p Neighboring gene glucose sensor Neighboring gene ribosomal 60S subunit protein L35B Neighboring gene Rdi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Different domains of mammalian ADP-ribosylation factor 1 mediate interaction with selected target proteins. Liang JO, et al. J Biol Chem, 1997 Dec 26. PMID 9407081
    2. Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans. Lodge JK, et al. J Biol Chem, 1994 Jan 28. PMID 8300631
    3. Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. Burnaevskiy N, et al. Nature, 2013 Apr 4. PMID 23535599, Free PMC Article
    4. Systematic structure-function analysis of the small GTPase Arf1 in yeast. Click ES, et al. Mol Biol Cell, 2002 May. PMID 12006660, Free PMC Article
    5. Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases. Amor JC, et al. J Biol Chem, 2001 Nov 9. PMID 11535602

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Arf family GTPase ARF2
    NP_010144.1
    • ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      216529..217074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180197.1 → NP_010144.1  TPA: Arf family GTPase ARF2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBP3, D6VRL1, P19146
      UniProtKB/TrEMBL
      A0A6A5PYY7, A6ZXJ0, B3LH28, B5VFD4, C7GKY9, C8Z6G5, G2WC24, N1P7N1
      Conserved Domains (1) summary
      smart00177
      Location:5 → 179
      ARF; ARF-like small GTPases; ARF, ADP-ribosylation factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19146.3

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