BOI2 Boi2p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: BOI2
Gene description: Boi2p
Primary source: FungiDB:YER114C
Locus tag: YER114C
See related: SGD:S000000916; AllianceGenome:SGD:S000000916; VEuPathDB:YER114C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BEB1
Summary: Enables phospholipid binding activity. Involved in several processes, including budding cell apical bud growth; septum digestion after cytokinesis; and vesicle fusion to plasma membrane. Located in cellular bud neck. Orthologous to human PLEKHA7 (pleckstrin homology domain containing A7). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
Title: Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
Title: The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
Title: Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in budding cell apical bud growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in septum digestion after cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle fusion to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular bud	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

NP_011039.1

Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain