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    CNA1 calcineurin catalytic subunit A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851153, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CNA1
    Official Full Name
    calcineurin catalytic subunit A
    Primary source
    SGD:S000004425
    Locus tag
    YLR433C
    See related
    AllianceGenome:SGD:S000004425; FungiDB:YLR433C; VEuPathDB:YLR433C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CMP1
    Summary
    Contributes to calcium-dependent protein serine/threonine phosphatase activity. Involved in several processes, including cellular response to pheromone; conjugation with cellular fusion; and fungal-type cell wall organization. Part of calcineurin complex. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PPP3CB (protein phosphatase 3 catalytic subunit beta); and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CNA1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1004347..1006008, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Atg23p Neighboring gene IMP dehydrogenase IMD3 Neighboring gene Tsr2p Neighboring gene Ecm30p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular characterization of the calmodulin-binding subunit gene (CMP1) of protein phosphatase 2B from Saccharomyces cerevisiae. An alpha-factor inducible gene. Ye RR, et al. Eur J Biochem, 1992 Mar 1. PMID 1311678
    2. The interaction between the catalytic A subunit of calcineurin and its autoinhibitory domain, in the yeast two-hybrid system, is disrupted by cyclosporin A and FK506. Chaudhuri B, et al. FEBS Lett, 1995 Jan 3. PMID 7528690
    3. Only in the presence of immunophilins can cyclosporin and FK506 disrupt in vivo binding of calcineurin A to its autoinhibitory domain yet strengthen interaction between calcineurin A and B subunits. Chaudhuri B, et al. Biochem Biophys Res Commun, 1995 Oct 13. PMID 7488022
    4. Knr4 N-terminal domain controls its localization and function during sexual differentiation and vegetative growth. Dagkessamanskaia A, et al. Yeast, 2010 Aug. PMID 20602333
    5. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions. Nakamura T, et al. EMBO J, 1993 Nov. PMID 7693452, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data report that heterologous expression of CaZF provides osmotolerance in S. cerevisiae through Hog1p and calcineurin dependent as well as independent pathways.
      Title: CaZF, a plant transcription factor functions through and parallel to HOG and calcineurin pathways in Saccharomyces cerevisiae to provide osmotolerance.
    2. ethanol activates the calcineurin/Crz1 pathway and CRZ1 is crucial for cell survival under ethanol-induced stress
      Title: Ethanol stress stimulates the Ca2+-mediated calcineurin/Crz1 pathway in Saccharomyces cerevisiae.
    3. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
      Title: A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
    4. Results demonstrate that calcineurin can positively regulate the transport of cations by the mutant allele VCX1-M1p.
      Title: Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p.
    5. target of rapamycin complex 2(TORC2)-SLM signaling negatively regulates calcineurin, and calcineurin negatively regulates TORC2-SLM
      Title: Mutual antagonism of target of rapamycin and calcineurin signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to calcium-dependent protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular monoatomic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of calcineurin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin catalytic subunit A
    NP_013537.1
    • Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1004347..1006008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182321.1 → NP_013537.1  TPA: calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013537.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ68, P23287
      UniProtKB/TrEMBL
      A7A1V3, B3RHU2, C7GSM2, G2WJP4, N1NZX1
      Conserved Domains (1) summary
      cd07416
      Location:70 → 381
      MPP_PP2B; PP2B, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23287.2

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