COQ1 trans-hexaprenyltranstransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COQ1
Official Full Name: trans-hexaprenyltranstransferase
Primary source: SGD:S000000207
Locus tag: YBR003W
See related: AllianceGenome:SGD:S000000207; FungiDB:YBR003W; VEuPathDB:YBR003W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables heptaprenyl diphosphate synthase activity. Involved in ubiquinone biosynthetic process. Is active in mitochondrion. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2 and primary coenzyme Q10 deficiency 3. Orthologous to several human genes including PDSS1 (decaprenyl diphosphate synthase subunit 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See COQ1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (242809..244230)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The product distribution in the strains indicated that the energy barrier could be the reason that different metal ion-assisted electrophilic attacks initiated carbocation formation.
Title: ERG9 and COQ1 disruption reveals isoprenoids biosynthesis is closely related to mitochondrial function in Saccharomyces cerevisiae.
Coq1 is functional when expressed alone in E. coli and in budding yeast, but is only functional as a partner with Dps1 in fission yeast.
Title: Heteromer formation of a long-chain prenyl diphosphate synthase from fission yeast Dps1 and budding yeast Coq1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables heptaprenyl diphosphate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in isoprenoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
part_of polyprenyl diphosphate synthase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: trans-hexaprenyltranstransferase

NP_009557.1

Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

242809..244230

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178351.1 → NP_009557.1 TPA: trans-hexaprenyltranstransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009557.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ04, P18900

UniProtKB/TrEMBL

A6ZKV0, B3LND7, C7GM46, C8Z3Z9, G2W911

Conserved Domains (1) summary

cl00210
Location:48 → 471

Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1