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    COX4 cytochrome c oxidase subunit IV [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852688, updated on 19-Jun-2024

    Summary

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    Gene symbol
    COX4
    Gene description
    cytochrome c oxidase subunit IV
    Primary source
    FungiDB:YGL187C
    Locus tag
    YGL187C
    See related
    SGD:S000003155; AllianceGenome:SGD:S000003155; VEuPathDB:YGL187C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables zinc ion binding activity. Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COX4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (149704..150171, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S26A Neighboring gene uncharacterized protein Neighboring gene Tpn1p Neighboring gene putative hydroxyacid dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily. Maréchal A, et al. Biochim Biophys Acta, 2012 Apr. PMID 21925484, Free PMC Article
    2. The characterization and role of zinc binding in yeast Cox4. Coyne HJ 3rd, et al. J Biol Chem, 2007 Mar 23. PMID 17215247
    3. Translational regulation of nuclear gene COX4 expression by mitochondrial content of phosphatidylglycerol and cardiolipin in Saccharomyces cerevisiae. Su X, et al. Mol Cell Biol, 2006 Feb. PMID 16428432, Free PMC Article
    4. Subunit IV of yeast cytochrome c oxidase: cloning and nucleotide sequencing of the gene and partial amino acid sequencing of the mature protein. Maarse AC, et al. EMBO J, 1984 Dec 1. PMID 6098449, Free PMC Article
    5. A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. Roise D, et al. EMBO J, 1986 Jun. PMID 3015598, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that Cox4 is a key factor for the biogenesis of complex IV, therefor mtHsp70-Mge1-Cox4 complex plays an important role in the formation of cytochrome c oxidase.
      Title: A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase.
    2. Studies indicate that Saccharomyces cerevisiae as a model system for mutation of mitochondrial cytochrome c oxidase subunits.
      Title: Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily.
    3. analysis of zinc binding in yeast Cox4
      Title: The characterization and role of zinc binding in yeast Cox4.
    4. Deletion analysis of the 5' UTR(COX4) revealed the presence of a 50-nucleotide fragment with two stem-loops as a cis-element inhibiting COX4 translation.
      Title: Translational regulation of nuclear gene COX4 expression by mitochondrial content of phosphatidylglycerol and cardiolipin in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit IV
    NP_011328.1
    • Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      149704..150171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181052.1 → NP_011328.1  TPA: cytochrome c oxidase subunit IV [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011328.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2TBN6, D6VTW7, P04037
      UniProtKB/TrEMBL
      A0A6A5PV33, A6ZU01, B3LHN6, C7GX07, C8Z865, G2WDR9, N1P6D5
      Conserved Domains (1) summary
      pfam01215
      Location:31 → 155
      COX5B; Cytochrome c oxidase subunit Vb
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04037.1

    Gene LinkOut

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