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    DCP1 Dcp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854016, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DCP1
    Official Full Name
    Dcp1p
    Primary source
    SGD:S000005509
    Locus tag
    YOL149W
    See related
    AllianceGenome:SGD:S000005509; FungiDB:YOL149W; VEuPathDB:YOL149W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRT2
    Summary
    Enables enzyme activator activity and mRNA binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body; cytoplasmic side of membrane; and nucleus. Part of RNA decapping complex. Orthologous to human DCP1A (decapping mRNA 1A) and DCP1B (decapping mRNA 1B). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See DCP1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (44938..45633)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative ferric-chelate reductase Neighboring gene methylglyoxal reductase (NADPH-dependent) GRE2 Neighboring gene Spt20p Neighboring gene Pex11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. mRNA-decapping enzyme from Saccharomyces cerevisiae: purification and unique specificity for long RNA chains. Stevens A. Mol Cell Biol, 1988 May. PMID 2838740, Free PMC Article
    2. An essential component of the decapping enzyme required for normal rates of mRNA turnover. Beelman CA, et al. Nature, 1996 Aug 15. PMID 8757137
    3. Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. LaGrandeur TE, et al. EMBO J, 1998 Mar 2. PMID 9482745, Free PMC Article
    4. Monitoring mRNA decapping activity. Zhang S, et al. Methods, 1999 Jan. PMID 10075882
    5. Analysis of mutations in the yeast mRNA decapping enzyme. Tharun S, et al. Genetics, 1999 Apr. PMID 10101156, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in P-body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of RNA decapping complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA decapping complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dcp1p
    NP_014492.1
    • Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      44938..45633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183403.1 → NP_014492.1  TPA: Dcp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1S0, Q12517
      UniProtKB/TrEMBL
      A6ZN63, B3LIR8, B5VRB2, C7GQ33, C8ZHG8, G2WM89, N1NY49
      Conserved Domains (1) summary
      cd09804
      Location:18 → 222
      Dcp1; mRNA decapping enzyme 1 (Dcp1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12517.1

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