ATG32 mitophagy protein ATG32 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ATG32
Gene description: mitophagy protein ATG32
Primary source: FungiDB:YIL146C
Locus tag: YIL146C
See related: SGD:S000001408; AllianceGenome:SGD:S000001408; VEuPathDB:YIL146C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ECM37
Summary: Involved in autophagy of mitochondrion and mitochondria-nucleus signaling pathway. Located in mitochondrion. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ATG32 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (74184..75773, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex.
Title: The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex.
Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy.
Title: Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy.
The yeast mitophagy receptor Atg32 is ubiquitinated and degraded by the proteasome.
Title: The yeast mitophagy receptor Atg32 is ubiquitinated and degraded by the proteasome.
Results reveal that a posttranslational modification discriminates a form of Atg32 targeting mitochondria for mitophagy from that, which escapes mitophagy by rapid degradation.
Title: The Degradation Pathway of the Mitophagy Receptor Atg32 Is Re-Routed by a Posttranslational Modification.
Amelioration of Atg32 expression and attenuation of Atg8-phosphatidylmonomethylethanolamine conjugation markedly rescue mitophagy in opi null cells.
Title: Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling.
Based on findings, authors conclude that the Tor and PpSin3-PpRpd3 pathway regulates PpAtg32 expression, but not PpAtg32 phosphorylation.
Title: Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.
data implicate Atg32 as a bipartite platform recruiting Atg8 and Atg11 to the mitochondrial surface and forming an initiator complex crucial for mitophagy.
Title: Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.
Phosphorylation of Serine 114 on Atg32 mediates mitophagy
Title: Phosphorylation of Serine 114 on Atg32 mediates mitophagy.
When mitophagy is induced, Atg32 binds to Atg11, an adaptor protein for selective autophagy.
Title: Atg32 is a tag for mitochondria degradation in yeast.
Atg32 is a transmembrane receptor that directs autophagosome formation to mitochondria.
Title: A landmark protein essential for mitophagy: Atg32 recruits the autophagic machinery to mitochondria.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondria-nucleus signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitophagy protein ATG32

NP_012120.1

Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

74184..75773 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179494.1 → NP_012120.1 TPA: mitophagy protein ATG32 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012120.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZVD0, B3LTZ3, B5VKG3, C7GUR3, C8ZAW6, D6VVE1, P40458

UniProtKB/TrEMBL

A0A8H4C1J4, N1P2D6

Conserved Domains (1) summary

cd19929
Location:204 → 341

psREC_Atg32; pseudo receiver domain of autophagy receptor Atg32