PHO2 Pho2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PHO2
Gene description: Pho2p
Primary source: FungiDB:YDL106C
Locus tag: YDL106C
See related: SGD:S000002264; AllianceGenome:SGD:S000002264; VEuPathDB:YDL106C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BAS2; GRF10
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription regulatory region DNA binding activity; regulation of histidine biosynthetic process; and regulation of nucleobase-containing compound metabolic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in anterior segment dysgenesis (multiple); cataract (multiple); and clubfoot. Orthologous to human DMBX1 (diencephalon/mesencephalon homeobox 1); PITX1 (paired like homeodomain 1); and PITX3 (paired like homeodomain 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PHO2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (270222..271901, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD[+] Metabolism with Phosphate Sensing in Saccharomyces cerevisiae.
Title: The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD(+) Metabolism with Phosphate Sensing in Saccharomyces cerevisiae.
From the experimental data it was inferred that the transcription factors Bas1p, Pho2p, and Gcn4p play a central role in the regulatory events causing the Crabtree effect in Saccharomyces cerevisiae.
Title: Gcn4p and the Crabtree effect of yeast: drawing the causal model of the Crabtree effect in Saccharomyces cerevisiae and explaining evolutionary trade-offs of adaptation to galactose through systems biology.
Data show that Bas1 is localized to the nucleus under both repressing and derepressing conditions, and that Pho2 is not required for the association of Bas1 with chromosomal DNA.
Title: DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI Inferred from Genetic Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription regulatory region DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of histidine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of purine nucleobase metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of purine nucleobase metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pho2p

NP_010177.1

Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

270222..271901 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180165.1 → NP_010177.1 TPA: Pho2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010177.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRP4, P07269

UniProtKB/TrEMBL

A0A8H8UMI4, C8Z6J8

Conserved Domains (1) summary

COG5576
Location:53 → 183

COG5576; Homeodomain-containing transcription factor [Transcription]