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    INH1 ATPase inhibitor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851347, updated on 2-Nov-2024

    Summary

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    Official Symbol
    INH1
    Official Full Name
    ATPase inhibitor
    Primary source
    SGD:S000002340
    Locus tag
    YDL181W
    See related
    AllianceGenome:SGD:S000002340; FungiDB:YDL181W; VEuPathDB:YDL181W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase inhibitor activity and enzyme inhibitor activity. Involved in negative regulation of ATP-dependent activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See INH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (135179..135436)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mrx19p Neighboring gene homocitrate synthase LYS20 Neighboring gene Ait1p Neighboring gene Pcl9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. How the N-terminal extremity of Saccharomyces cerevisiae IF1 interacts with ATP synthase: a kinetic approach. Andrianaivomananjaona T, et al. Biochim Biophys Acta, 2011 Feb. PMID 20951672
    2. A protein inhibitor of mitochondrial adenosine triphosphatase (F1) from Saccharomyces cerevisiae. Ebner E, et al. J Biol Chem, 1977 Jan 25. PMID 137903
    3. Binding of intrinsic ATPase inhibitor to mitochondrial ATPase--stoichiometry of binding of nucleotides, inhibitor, and enzyme. Hashimoto T, et al. J Biochem, 1981 Oct. PMID 6458600
    4. Amino acid sequence of an intrinsic inhibitor of mitochondrial ATPase from yeast. Matsubara H, et al. J Biochem, 1981 Oct. PMID 6458601
    5. Partial amino terminal sequence of the precursor of mitochondrial ATPase inhibitor protein synthesized with mRNA partially purified by gel permeation chromatography. Yoshida Y, et al. J Biochem, 1983 Jul. PMID 6619114

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of ATP-dependent activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATPase inhibitor
    NP_010100.1
    • Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      135179..135436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180241.1 → NP_010100.1  TPA: ATPase inhibitor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010100.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRH1, P01097
      UniProtKB/TrEMBL
      A6ZXF0, B3LH65, C7GL27, C8Z6C3, G2WBY4, N1P7C4
      Conserved Domains (1) summary
      pfam04568
      Location:4 → 85
      IATP; Mitochondrial ATPase inhibitor, IATP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01097.2

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