U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    KEX1 serine-type carboxypeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852670, updated on 29-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    KEX1
    Gene description
    serine-type carboxypeptidase
    Primary source
    FungiDB:YGL203C
    Locus tag
    YGL203C
    See related
    SGD:S000003171; AllianceGenome:SGD:S000003171; VEuPathDB:YGL203C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables serine-type carboxypeptidase activity. Involved in apoptotic process. Located in trans-Golgi network. Human ortholog(s) of this gene implicated in galactosialidosis and lysosomal storage disease. Orthologous to human CTSA (cathepsin A). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KEX1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (112475..114664, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene uncharacterized protein Neighboring gene tRNA-Lys Neighboring gene bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Disruption of the KEX1 gene in Pichia pastoris allows expression of full-length murine and human endostatin. Boehm T, et al. Yeast, 1999 May. PMID 10341419
    2. Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae. Shilton BH, et al. Protein Sci, 1996 Feb. PMID 8745419, Free PMC Article
    3. Expression, purification, and characterization of the yeast KEX1 gene product, a polypeptide precursor processing carboxypeptidase. Latchinian-Sadek L, et al. J Biol Chem, 1993 Jan 5. PMID 8416959
    4. Secretion, purification and characterization of a soluble form of the yeast KEX1-encoded protein from insect-cell cultures. Latchinian-Sadek L, et al. Eur J Biochem, 1994 Jan 15. PMID 8307029
    5. Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing. Dmochowska A, et al. Cell, 1987 Aug 14. PMID 3301004

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The protease Kex1p appears to mediate HOClinduced lethality, since its absence enhances cell viability and decreases levels of ROS as well as formation of HOCl-modified epitopes upon challenge with lethal doses of HOCl.
      Title: The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast.
    2. Kex1 contributes also to the active cell death program induced by acetic acid stress or during chronological aging, suggesting that Kex1 plays a more general role in cellular suicide of yeast.
      Title: Kex1 protease is involved in yeast cell death induced by defective N-glycosylation, acetic acid, and chronological aging.
    3. Kex2 and Kex1 may promote cell fusion by proteolytically processing substrates that act in parallel to Prm1 as an alternative fusion machine, as cell wall components, or both.
      Title: The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    serine-type carboxypeptidase
    NP_011312.1
    • Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      112475..114664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181068.1 → NP_011312.1  TPA: serine-type carboxypeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011312.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTV1, P09620
      UniProtKB/TrEMBL
      A0A8H4C2G5, G2WDQ4
      Conserved Domains (1) summary
      COG2939
      Location:1 → 498
      Kex1; Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09620.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools