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    MDM20 Mdm20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854079, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDM20
    Official Full Name
    Mdm20p
    Primary source
    SGD:S000005436
    Locus tag
    YOL076W
    See related
    AllianceGenome:SGD:S000005436; FungiDB:YOL076W; VEuPathDB:YOL076W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DEC1; NAA25
    Summary
    Contributes to peptide alpha-N-acetyltransferase activity. Involved in several processes, including N-terminal peptidyl-methionine acetylation; mitochondrion inheritance; and regulation of actin cytoskeleton organization. Part of NatB complex. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MDM20 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (187024..189414)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit k Neighboring gene ribosome biogenesis protein BRX1 Neighboring gene uncharacterized protein Neighboring gene Dsc2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Singer JM, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12808144, Free PMC Article
    2. Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions. Singer JM, et al. Genetics, 2000 Oct. PMID 11014803, Free PMC Article
    3. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast. Bleazard W, et al. Nat Cell Biol, 1999 Sep. PMID 10559943, Free PMC Article
    4. Improper organization of the actin cytoskeleton affects protein synthesis at initiation. Gross SR, et al. Mol Cell Biol, 2007 Mar. PMID 17178834, Free PMC Article
    5. Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. Polevoda B, et al. J Biol Chem, 2003 Aug 15. PMID 12783868

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to peptide alpha-N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in N-terminal peptidyl-methionine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatB complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mdm20p
    NP_014566.1
    • Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      187024..189414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183330.1 → NP_014566.1  TPA: Mdm20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014566.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Z2, Q12387
      UniProtKB/TrEMBL
      A6ZND5, N1NZ50
      Conserved Domains (1) summary
      pfam09797
      Location:270 → 591
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12387.1

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