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    SPC29 Spc29p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855979, updated on 17-May-2024

    Summary

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    Gene symbol
    SPC29
    Gene description
    Spc29p
    Primary source
    FungiDB:YPL124W
    Locus tag
    YPL124W
    See related
    SGD:S000006045; AllianceGenome:SGD:S000006045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPH3; NIP29
    Summary
    Predicted to be a structural constituent of cytoskeleton. Involved in mitotic spindle pole body duplication. Located in spindle pole body. Is active in central plaque of mitotic spindle pole body. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPC29 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (316755..317516)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Nan1p Neighboring gene Kap120p Neighboring gene ribonuclease T2 Neighboring gene TFIIH/NER complex subunit TFB2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation. Holinger EP, et al. J Biol Chem, 2009 May 8. PMID 19269975, Free PMC Article
    2. Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast. Xu S, et al. Curr Biol, 2000 Mar 23. PMID 10744974
    3. The N-terminus of Sfi1 and yeast centrin Cdc31 provide the assembly site for a new spindle pole body. Rüthnick D, et al. J Cell Biol, 2021 Mar 1. PMID 33523111, Free PMC Article
    4. Yeast pericentrin/Spc110 contains multiple domains required for tethering the γ-tubulin complex to the centrosome. Alonso A, et al. Mol Biol Cell, 2020 Jul 1. PMID 32374651, Free PMC Article
    5. Analysis of coiled-coil interactions between core proteins of the spindle pole body. Zizlsperger N, et al. Biochemistry, 2008 Nov 11. PMID 18850724

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle pole body duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle pole body duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in central plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in central plaque of spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body HDA PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spc29p
    NP_015201.1
    • Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      316755..317516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183938.1 → NP_015201.1  TPA: Spc29p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015201.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LKV0, B5VT41, C7GJ78, C8ZIQ5, D6W3P3, E7KVI3, E7M1C7, E7QLB7, P33419
      UniProtKB/TrEMBL
      A0A8H4BUZ9, N1NVV8
      Conserved Domains (1) summary
      pfam17082
      Location:1 → 251
      Spc29; Spindle Pole Component 29
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33419.1

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