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    NIT3 putative hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851065, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NIT3
    Official Full Name
    putative hydrolase
    Primary source
    SGD:S000004343
    Locus tag
    YLR351C
    See related
    AllianceGenome:SGD:S000004343; FungiDB:YLR351C; VEuPathDB:YLR351C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in amide catabolic process. Located in mitochondrion. Orthologous to human NIT2 (nitrilase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NIT3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (829489..830364, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Dic1p Neighboring gene sphingolipid homeostasis protein ORM2 Neighboring gene Lug1p Neighboring gene Bud8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a putative CN hydrolase from yeast. Kumaran D, et al. Proteins, 2003 Aug 1. PMID 12833551
    2. Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. Pace HC, et al. Curr Biol, 2000 Jul 27-Aug 10. PMID 10959838
    3. Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1. Creamer TJ, et al. PLoS Genet, 2011 Oct. PMID 22028667, Free PMC Article
    4. Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Peracchi A, et al. Proc Natl Acad Sci U S A, 2017 Apr 18. PMID 28373563, Free PMC Article
    5. The proteome of Saccharomyces cerevisiae mitochondria. Sickmann A, et al. Proc Natl Acad Sci U S A, 2003 Nov 11. PMID 14576278, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega-amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables omega-amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in asparagine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    putative hydrolase
    NP_013455.1
    • Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      829489..830364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182240.1 → NP_013455.1  TPA: putative hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYY9, P49954, Q71SP9
      UniProtKB/TrEMBL
      A7A1M9, B3RHM0, B5VNP1, C7GRX6, C8ZDV9, G2WJG9, N1P777
      Conserved Domains (1) summary
      cd07572
      Location:12 → 281
      nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49954.1

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