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    NUP49 FG-nucleoporin NUP49 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852703, updated on 29-Jun-2024

    Summary

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    Gene symbol
    NUP49
    Gene description
    FG-nucleoporin NUP49
    Primary source
    FungiDB:YGL172W
    Locus tag
    YGL172W
    See related
    SGD:S000003140; AllianceGenome:SGD:S000003140; VEuPathDB:YGL172W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NSP49
    Summary
    A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport. Located in nuclear envelope. Part of nuclear pore central transport channel. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NUP49 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (180700..182118)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Bud13p Neighboring gene chromatin-binding exonuclease XRN1 Neighboring gene RNA-dependent ATPase ROK1 Neighboring gene Spo74p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sequence of an 11.1 kb fragment on the left arm of Saccharomyces cerevisiae chromosome VII reveals six open reading frames including NSP49, KEM1 and four putative new genes. Bertani I, et al. Yeast, 1995 Sep 30. PMID 8619317
    2. Unexplored Cdc42 functions at the budding yeast nucleus suggested by subcellular localization. Lu MS, et al. Small GTPases, 2022 Jan. PMID 34689711, Free PMC Article
    3. Dynamics of nuclear pore distribution in nucleoporin mutant yeast cells. Belgareh N, et al. J Cell Biol, 1997 Feb 24. PMID 9049242, Free PMC Article
    4. Reconstitution of nuclear protein transport with semi-intact yeast cells. Schlenstedt G, et al. J Cell Biol, 1993 Nov. PMID 8227140, Free PMC Article
    5. A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution. Doye V, et al. EMBO J, 1994 Dec 15. PMID 7813444, Free PMC Article

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere tethering at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore central transport channel IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore cytoplasmic filaments IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FG-nucleoporin NUP49
    NP_011343.1
    • FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      180700..182118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181037.1 → NP_011343.1  TPA: FG-nucleoporin NUP49 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTY0, Q02199
      UniProtKB/TrEMBL
      A0A8H4C001, G2WDT3, N1P6F0
      Conserved Domains (2) summary
      cl14654
      Location:267 → 465
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      pfam15967
      Location:29 → 289
      Nucleoporin_FG2; Nucleoporin FG repeated region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02199.1

    Gene LinkOut

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