PDR10 ATP-binding cassette multidrug transporter PDR10 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: PDR10
Gene description: ATP-binding cassette multidrug transporter PDR10
Primary source: FungiDB:YOR328W
Locus tag: YOR328W
See related: SGD:S000005855; AllianceGenome:SGD:S000005855; VEuPathDB:YOR328W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in replication-born double-strand break repair via sister chromatid exchange. Located in plasma membrane. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to several human genes including ABCA10 (ATP binding cassette subfamily A member 10); ABCA3 (ATP binding cassette subfamily A member 3); and ABCA5 (ATP binding cassette subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in replication-born double-strand break repair via sister chromatid exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_014973.1

ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p

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The following sections contain reference sequences that belong to a specific genome build. Explain