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    QRI7 putative N(6)-L-threonylcarbamoyladenine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851454, updated on 9-Jun-2024

    Summary

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    Gene symbol
    QRI7
    Gene description
    putative N(6)-L-threonylcarbamoyladenine synthase
    Primary source
    FungiDB:YDL104C
    Locus tag
    YDL104C
    See related
    SGD:S000002262; AllianceGenome:SGD:S000002262; VEuPathDB:YDL104C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables N(6)-L-threonylcarbamoyladenine synthase activity. Involved in mitochondrial tRNA threonylcarbamoyladenosine modification. Located in mitochondrion. Orthologous to human OSGEPL1 (O-sialoglycoprotein endopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See QRI7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (273653..274876, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Pho2p Neighboring gene Smc5-Smc6 complex subunit NSE4 Neighboring gene UDP-N-acetylglucosamine diphosphorylase Neighboring gene DNA-directed DNA polymerase delta POL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP. Tominaga T, et al. Acta Crystallogr F Struct Biol Commun, 2014 Aug. PMID 25084372, Free PMC Article
    2. A substrate binding model for the KEOPS tRNA modifying complex. Beenstock J, et al. Nat Commun, 2020 Dec 4. PMID 33277478, Free PMC Article
    3. A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification. El Yacoubi B, et al. EMBO J, 2011 Mar 2. PMID 21285948, Free PMC Article
    4. Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity. Li QX, et al. Biochem J, 2022 Dec 9. PMID 36416748
    5. Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes. Thiaville PC, et al. Eukaryot Cell, 2014 Sep. PMID 25038083, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results firmly established that Qri7p and Sua5p constitute the mitochondrial pathway for the biosynthesis of t(6)A and bring additional advancement in our understanding of the reaction mechanism
      Title: Cross kingdom functional conservation of the core universally conserved threonylcarbamoyladenosine tRNA synthesis enzymes.
    2. The manner of AMP recognition is similar, with some minor variations, among the Qri7/Kae1/YgjD family proteins
      Title: Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP.
    3. Qri7/OSGEPL protein localizes to the mitochondria and is involved in mitochondrial genome maintenance in the model eukaryotic organism, Saccharomyces cerevisiae.
      Title: Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N(6)-L-threonylcarbamoyladenine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N(6)-L-threonylcarbamoyladenine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA threonylcarbamoyladenosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA threonylcarbamoyladenosine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA threonylcarbamoyladenosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative N(6)-L-threonylcarbamoyladenine synthase
    NP_010179.1
    • Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      273653..274876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180163.1 → NP_010179.1  TPA: putative N(6)-L-threonylcarbamoyladenine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010179.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRP6, P43122
      UniProtKB/TrEMBL
      A0A8H8UMI6, A6ZXM5, C8Z6K0
      Conserved Domains (1) summary
      TIGR00329
      Location:36 → 367
      gcp_kae1; metallohydrolase, glycoprotease/Kae1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43122.1

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